93863-41-3

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 105-45-3 acetoacetic acid methyl ester 
• 70017-27-5 3-(2,4-Dichlorophenyl)propenal 

Downstream Products

• 93863-42-4 methyl (E)-6-[2-(2,4-dichlorophenyl)-ethenyl]-5,6-dihydro-4-hydroxy-2H-pyran-2-one 
• 93863-43-5 methyl (E)-7-(2,4-dichlorophenyl)-3,5-dihydroxy-6-heptenoate 
• 86097-38-3 cis-(E)-6-[2-(2,4-dichlorophenyl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 78444-39-0 (-)-trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 93863-44-6 (2R*,4R*,6S*)-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-4-hydroxy-2-methoxy-3,4,5,6-tetrahydropyran 
• 86097-55-4 trans-(E)-6-<2-(2,4-dichlorophenyl)ethyl>-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 93863-45-7 erythro-(E)-7-(2,4-dichlorophenyl)-3,5-dihydroxy-6-heptenamide 
• 86097-37-2 Trans-(E)-6-[2-(2,4-dichlorophenyl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 86097-37-2 trans-(E)-6-[2-(2,4-dichlorophenyl)ethenyl]-3,4,5,6-tetrahydro-4-hydroxy-2H-pyran-2-one 
• 93922-58-8 (2S*,4R*,6S*)-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-4-hydroxy-2-methoxy-3,4,5,6-tetrahydropyran 
• 93863-87-7 (4R,6S)-6-[(E)-2-(2,4-Dichloro-phenyl)-vinyl]-tetrahydro-pyran-2,4-diol 

Relevant academic research and scientific papers

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives

A series of 5-substituted 3,5-dihydroxypentanoic acids and their derivatives have been prepared and tested for inhibition of HMG-CoA reductase in vitro. In general, unless a carboxylate anion can be formed and the hydroxy groups remain unsubstituted in an erythro relationship, inhibitory activity is greatly reduced. Furthermore, only one enantiomer of the ring-opened form of lactone 6a(±) possesses the activity displayed by the racemate. Insertion of a bridging unit other than ethyl or (E)-ethenyl between the 5-carbinol moiety and an appropriate lipophilic moiety (e.g., 2,4-dichlorophenyl) attenuates activity.