93863-47-9

Upstream product

• 598-21-0 2-Bromoacetyl bromide 
• 93863-46-8 6-(2,4-dichlorophenyl)-4-hydroxy-5-hexen-2-one 
• 70017-27-5 3-(2,4-Dichlorophenyl)propenal 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 93863-52-6 trans-6-<2-(2,4-dichlorophenyl)ethyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one 
• 93863-53-7 trans-6-<2-(2,4-dichlorophenyl)ethyl>-5,6-dihydro-4-methyl-2H-pyran-2-one 
• 93863-48-0 trans-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one 
• 93863-49-1 cis-(E)-6-<2-(2,4-dichlorophenyl)ethenyl>-3,4,5,6-tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one 

Relevant academic research and scientific papers

Substituted pyranone inhibitors of cholesterol synthesis

The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihydroxy-6-heptenoic acid of structural formula: STR1 are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives

A series of 5-substituted 3,5-dihydroxypentanoic acids and their derivatives have been prepared and tested for inhibition of HMG-CoA reductase in vitro. In general, unless a carboxylate anion can be formed and the hydroxy groups remain unsubstituted in an erythro relationship, inhibitory activity is greatly reduced. Furthermore, only one enantiomer of the ring-opened form of lactone 6a(±) possesses the activity displayed by the racemate. Insertion of a bridging unit other than ethyl or (E)-ethenyl between the 5-carbinol moiety and an appropriate lipophilic moiety (e.g., 2,4-dichlorophenyl) attenuates activity.

Substituted pyranone inhibitors of cholesterol synthesis

6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS

6-Phenyl-, phenylalkyl-and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductas