93867-16-4Relevant academic research and scientific papers
Synthesis of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives as potential allosteric modulators of AMPA/kainate receptors
Braghiroli, Daniela,Puia, Giulia,Cannazza, Giuseppe,Tait, Annalisa,Parenti, Carlo,Losi, Gabriele,Baraldi, Mario
, p. 2355 - 2357 (2007/10/03)
A series of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide derivatives were synthesized and evaluated for their activity as allosteric modulators of kainate-activated currents in primary cultures of cerebellar granule neurons. Substitution of different groups at the 3-position of the benzothiadiazine ring distinguished between positive and negative allosteric modulatory properties.
