93875-52-6Relevant academic research and scientific papers
Iron-Catalyzed Room Temperature Cross-Couplings of Bromophenols with Aryl Grignard Reagents
Xu, Li-Chen,Liu, Kun-Ming,Duan, Xin-Fang
supporting information, p. 5421 - 5427 (2019/11/14)
Herein we report a room temperature Fe-catalyzed coupling reaction of various bromophenols with aryl Grignard reagents, which exhibits a wide substrate scope and high functional group tolerance. For the first time, the combination of simple Fe(acac)3/PBu3/Ti(OEt)4 has been used as an effective catalyst for the biaryl couplings of bromophenols or their Na or K salts with debromination and etherification side reactions being well suppressed. Various biphenols including natural product garcibiphenyl C as well as pharmaceutical diflunisal and its ethyl ester were facilely synthesized using the present protocol. (Figure presented.).
Application of dimeric orthopalladated complex in Suzuki-Miyaura cross coupling reaction under microwave irradiation and conventional heating
Hajipour, Abdol R.,Karami, Kazem,Pirisedigh, Azadeh
experimental part, p. 531 - 535 (2011/06/23)
The Suzuki-Miyaura reaction of various aryl halides using [Pd{C 6H2(CH2CH2NH2)-(OMe) 2,3,4} (μ-Br)]2 have been investigated. This orthopalladated complex is an efficient, stable and non-sensitive to air and moisture catalyst for the hetrocoupling reaction in DMF as the reaction solvent at 130 °C. The combination of dimeric complex as homogenous catalyst and microwave irradiation can be very useful and efficient methods in organic synthesis, so the application of microwave irradiation have been investigated using homogenous dimeric complex [Pd{C6H2(CH 2CH2NH2)-(OMe)2,3,4} (μ-Br)] 2. Application of dimeric complex as catalyst caused to produce the desired coupling products and the using of microwave irradiation improving the yields of the reactions and shortening the reaction times.
Exploring the selectivity of the Suzuki-Miyaura cross-coupling reaction in the synthesis of arylnaphthalenes
Lima, Carlos F.R.A.C.,Rodriguez-Borges, José E.,Santos, Luís M.N.B.F.
experimental part, p. 689 - 697 (2011/03/19)
A series of 1-arylnaphthalenes and 1,8-diarylnaphthalenes were synthesized by the Suzuki-Miyaura cross-coupling methodology showing significant differentiation in the yields and selectivity between aryl rings with electron donating (higher yields), and el
