93882-12-3 Usage
Uses
Used in Pharmaceutical Industry:
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a research compound for studying the role of cyclic nucleotides in cellular signaling and their potential therapeutic applications.
Used in Glucose Production Assay:
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as an activator of cGK and cAMP-PK to upregulate the cellular cholesterol pump (adenosine triphosphate(ATP-) binding cassette (ABC) transporter-1, ABCA-1), which plays a crucial role in maintaining cholesterol homeostasis and glucose production.
Used in Airway Epithelia:
8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT is used as a stimulator of the cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia. This application is particularly relevant for the treatment of cystic fibrosis, a genetic disorder characterized by the buildup of thick, sticky mucus in the lungs, leading to chronic respiratory infections and inflammation. By stimulating the CFTR channel, 8-CPT-cAMP can help improve the transport of chloride ions and water across the epithelial cells, thereby reducing mucus viscosity and facilitating its clearance from the airways.
Biological Activity
ka : 0.05 and 0.11 μm for pka and pkg, respectively8-cpt-cyclic amp is a lipophilic activator of the cyclic-amp- and cyclic-gmp-dependent protein kinases, pka and pkg.the ability of cgmp-dependent protein kinases (cgks) to activate camp response element (cre)-dependent gene transcription was compared with that of camp-dependent protein kinases (caks).
Biochem/physiol Actions
Cell permeable: yes
in vitro
a previous study found that 8-cpt-cyclic amp was a potent activator of camp-pk and cyclic-gmp-dependent protein kinase (cgmp-pk) both as purified enzymes and in platelet membranes. 8-cpt-cyclic amp was hydrolysed to a significant extent by the ca2+/calmodulin-dependent phosphodiesterase and by the cgmp-inhibited phosphodiesterase. moreover, sp-5,6- dcl-cbimps was also more effective than 8-cpt-cyclic amp in inducing quantitative phosphorylation of vasodilator-stimulated phosphoprotein in intact platelets [1]. another study indicated that 8-cpt-cyclic amp was a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). indeed, 8-cpt-cyclic amp could inhibit pde va with a potency similar to that of zaprinast. in addition, 8-cpt-cyclic amp was metabolized by pde va at a rate half that of cyclic gmp. the cyclic gmp-inhibited phosphodiesterase and the cyclic amp-specific phosphodiesterase could be inhibited by 8-cpt-cyclic amp as well [2].
references
[1] sandberg, m. ,butt, e.,nolte, c., et al. characterization of sp-5,6-dichloro-1-β-d-ribofuranosylbenzimidazole-3',5'-monophosphorothioate (sp-5,6-dcl-cbimps) as a potent and specific activator of cyclic-amp-dependent protein kinase in cell extracts and intact cells. biochemistry journal 279, 521-527 (1991).[2] connolly, b. j.,willits, p.b.,warrington, b.h., et al. 8-(4-chlorophenyl)thio-cyclic amp is a potent inhibitor of the cyclic gmp-specific phosphodiesterase (pde va). biochemical pharmacology 44(12), 2303-2306 (1992).
Check Digit Verification of cas no
The CAS Registry Mumber 93882-12-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,3,8,8 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 93882-12:
(7*9)+(6*3)+(5*8)+(4*8)+(3*2)+(2*1)+(1*2)=163
163 % 10 = 3
So 93882-12-3 is a valid CAS Registry Number.
