93885-69-9

Basic information

• Product Name: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4(1H,3H)-pyrimidinedione
• Synonyms: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4(1H,3H)-pyrimidinedione;TriMethopriM iMpurity 2;5-[(3,4,5-trimethoxyphenyl)methyl]-1H-pyrimidine-2,4-dione
• CAS NO: 93885-69-9
• Molecular Formula: C₁₄H₁₆N₂O₅
• Molecular Weight: 292.28724
• Mol File: 93885-69-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.253
• CAS DataBase Reference: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4(1H,3H)-pyrimidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4(1H,3H)-pyrimidinedione(93885-69-9)
• EPA Substance Registry System: 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4(1H,3H)-pyrimidinedione(93885-69-9)

Safety Data

• Hazardous Substances Data: 93885-69-9(Hazardous Substances Data)

Usage

Uses

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diol is an impurity of Trimethoprim(T795615), an antibacterial agent.

Upstream product

• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 910859-93-7 diethyl 3,4,5-trimethoxybenzyl phosphate 
• 910859-94-8 2,4-di-tert-butoxy-5-(3,4,5-trimethoxybenzyl)pyrimidine 

Downstream Products

• 738-70-5 5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine 

Relevant articles and documents

Synthesis of functionalized diarylmethanes via a copper-catalyzed cross-coupling of arylmagnesium reagents with benzylic phosphates

A combination of copper chloride, triethyl phosphite, and tetrabutylammonium iodide is a very efficient catalytic system for the synthesis of polyfunctionalized diarylmethanes, using the cross-coupling reaction of arylmagnesium halides with benzylic phosphates. The antibiotic Trimethoprim has been prepared using this Cu(I)-catalyzed cross-coupling in 52% overall yield (four steps).