939040-21-8Relevant articles and documents
Synthesis, biological testing, and binding mode prediction of 6,9-diarylpurin-8-ones as p38 MAP kinase inhibitors
Hauser, Dominik R. J.,Scior, Thomas,Domeyer, David M.,Kammerer, Bernd,Laufer, Stefan A.
, p. 2060 - 2066 (2007/10/03)
Based on the purine scaffold of ATP, derivatives of 6,9-diarylpurine-8-one were prepared and tested for their ability to inhibit p38 MAP kinase, a key enzyme in the cellular regulation of proinflammatory cytokines. The inhibitor design combines the purine