939053-53-9

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 1427216-72-5 2-hydroxy-4-oxo-4-(2-methoxyphenyl)but-2-enoic acid ethyl ester 
• 105434-90-0 5-amino-1H-pyrazole-3-carboxylic acid ethyl ester 
• 39846-84-9 5-nitro-1H-pyrazole-3-carboxylic acid ethyl ester 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 141998-77-8 ethyl 5-iodo-1H-pyrazole-3-carboxylate 
• 60943-39-7 ethyl 4-(2-methoxyphenyl)-2,4-dioxobutanoate 

Relevant academic research and scientific papers

POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER

Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.

On water synthesis of N-unsubstituted pyrazoles: Semicarbazide hydrochloride as an alternative to hydrazine for preparation of pyrazole-3-carboxylate derivatives and 3,5-disubstituted pyrazoles

A green, simple and highly efficient method for the synthesis of pyrazole-3-carboxylates and 3,5-disubstituted pyrazoles by cyclization of 4-aryl(hetaryl, alkyl)-2,4-diketoesters and 1,3-diketones with semicarbazide hydrochloride under on water conditions has been developed. This method also does not require toxic hydrazine and product purification, eliminating the use of toxic liquid chemicals.

One-pot synthesis of pyrazole-5-carboxylates by cyclization of hydrazone 1,4-dianions with diethyl oxalate

The cyclization of hydrazone dianions with diethyl oxalate afforded pyrazole-5-carboxylates.

GLUCOKINASE ACTIVATORS

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.