93929-51-2Relevant academic research and scientific papers
Total synthesis of (RS)- And (R)-3-alkanosyl-5-hydroxymethyltetronic acid homologues, HIV-1 protease inhibitory natural products
Yamashita, Masayuki,Murai, Hiromichi,Mittra, Asmita,Yoshioka, Tomomichi,Kawasaki, Ikuo,Gotoh, Mariko,Higashi, Tomoko,Hatsuyama, Rie,Ohta, Shunsaku
, p. 2327 - 2337 (2007/10/03)
5-Acetoxymethyl-γ-butyrolactone-3-carboxylic acids [(RS)-4a and (S)-4a] were prepared as racemic form starting from dibenzyl allylmalonate (5b) and optically active S form starting from (4S)-4-[2,2-bis(benzyloxycarbonyl)ethyl]-2,2-dimethyl-1,3-dioxolane [
A Useful Oxidation Procedure for the Preparation of 3-Alkanoyltetronic Acids
Mittra, Asmita,Yamashita, Masayuki,Kawasaki, Ikuo,Murai, Hiromichi,Yoshioka, Tomomichi,Ohta, Shunsaku
, p. 909 - 910 (2007/10/03)
An easy and convenient synthesis of 3-alkanoyl-5-hydroxymethyltetronic acids, the salts of which have inhibitory activity against HIV-1 protease, is described and a new direct route to 1,3-dicarbonylester from cyclic β-ketoester is developed.
