93939-80-1Relevant academic research and scientific papers
O-Substituted 7β-amino-3-cephem-3-ol-4-carboxylic acid compounds
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, (2008/06/13)
The invention relates to O-substituted 7β-amino-3-cephem-3-ol-4-carboxylic acid compounds of the formula STR1 wherein X represents amino or substituted amino, R2 represents hydroxyl or a group R2A which together with the carbonyl grouping --C(=O)-- forms a protected carboxyl group and R3 represents an optionally substituted hydrocarbon radical or an acyl group, and to 1-oxides of 3-cephem compounds of the formula IA, and also to the corresponding 2-cephem compounds of the formula STR2 wherein X, R2 and R3 have the abovementioned meanings, or salts of such compounds with salt-forming groups. 3-Cephem compounds of the formula IA, particularly those, in which X represents an amino group, R2 is hydroxy and R3 is lower alkyl exhibit pronounced antimicrobial effects, the others, and particularly the 1-oxides of these 3-cephem compounds and the corresponding 2-cephem compounds are useful as intermediates.
