93940-28-4

Usage

InChI:InChI=1/C18H24O/c1-17(2)8-9-18(3,4)15-11-13-12(10-14(15)17)6-5-7-16(13)19/h10-11H,5-9H2,1-4H3

Upstream product

• 1026950-90-2 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-butyryl chloride 
• 6683-46-1 1,1,4,4-Tetramethyl-1,2,3,4-tetrahydro-naphthalene 
• 119028-72-7 ethyl 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-oxo butyrate 
• 119028-65-8 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)-4-oxo butyric acid 
• 119028-91-0 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthyl)butyric acid 

Downstream Products

• 158302-78-4 methyl 4-<(3,4,5,6,7,8-hexahydro-5,5,8,8-tetramethyl-1(2H)-oxoanthracen-2-yl)hydroxymethyl>benzoate 
• 158302-61-5 4-(4,5,7,8,9,10-Hexahydro-7,7,10,10-tetramethylanthra-[1,2-b]furan-2-yl)benzoic acid 
• 158301-55-4 4-(1-Ethyl-4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethylanthra[2,1-d]pyrazol-3yl)benzoic acid 
• 1027497-00-2 4-(7,7,10,10-Tetramethyl-2-pyridin-3-ylmethyl-4,5,7,8,9,10-hexahydro-2H-naphtho[2,3-g]indazol-3-yl)-benzoic acid methyl ester 
• 1026480-34-1 4-(7,7,10,10-Tetramethyl-1-pyridin-3-ylmethyl-4,5,7,8,9,10-hexahydro-1H-naphtho[2,3-g]indazol-3-yl)-benzoic acid methyl ester 
• 1027449-10-0 4-(2-Benzyl-7,7,10,10-tetramethyl-4,5,7,8,9,10-hexahydro-2H-naphtho[2,3-g]indazol-3-yl)-benzoic acid methyl ester 
• 1026480-57-8 4-(1-Benzyl-7,7,10,10-tetramethyl-4,5,7,8,9,10-hexahydro-1H-naphtho[2,3-g]indazol-3-yl)-benzoic acid methyl ester 
• 169300-48-5 4-(2-Ethoxy-8,8,11,11-tetramethyl-3,4,5,6,8,9,10,11-octahydro-2H-1-oxa-benzo[a]anthracen-4-yl)-benzoic acid methyl ester 
• 1026614-17-4 4-(2,7,7,10,10-Pentamethyl-4,5,7,8,9,10-hexahydro-2H-naphtho[2,3-g]indazol-3-yl)-benzoic acid methyl ester 
• 158302-76-2 4-(4,5,7,8,9,10-hexahydro-1,7,7,10,10-pentamethylanthra<2,1-d>pyrazol-3-yl)benzoic acid methyl ester 
• 158302-74-0 methyl 4-(4,5,7,8,9,10-hexahydro-7,7,10,10-tetramethylanthra<2,1-d>pyrazol-3-yl)benzoate 
• 158302-88-6 4-(8,8,11,11-Tetramethyl-5,6,8,9,10,11-hexahydro-naphtho[2,3-h]quinolin-4-yl)-benzoic acid methyl ester 

Relevant academic research and scientific papers

Tricyclic retinoids, methods for their production and use

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

Tricyclic retinoids, methods for their production and use

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

Tricyclic retinoids, methods for their production and use

Tricyclic retinoids having activity for retinoic acid receptors and/or retinoid X receptors are provided. Also provided are pharmaceutical compositions incorporating such tricyclic retinoid compounds and methods for their therapeutic use.

A novel type of retinoic acid receptor antagonist: Synthesis and structure-activity relationships of heterocyclic ring-containing benzoic acid derivatives

A new series of heterocyclic ring-containing benzoic acids was prepared, and the binding affinity and antagonism of its members against all-trans- retinoic acid were evaluated by in vitro assay systems using human promyelocytic leukemia (HL-60) cells. Structure-activity relationships indicated that both an N-substituted pyrrole or pyrazole (1-position) and a hydrophobic region, with these linked by a ring system, were indispensable for effective antagonism. Among the compounds evaluated, optimal antagonism was exhibited by 4-[4,5,7,8,9,10-hexahydro-7,7,10,-10-tetramethyl-1-(3- pyridylmethyl)anthra[1,2-b]pyrrol-3-yl]benzoic acid (31), 4-[4,5,7,8,9,10- hexahydro-7,7,10,10-tetramethyl-1-(3-pyridylmethyl)-5-thiaanthra[1,2- b]pyrrol-3-yl]benzoic acid (40), and 4-[4,5,7,8,9,10-hexahydro-7,7,10,10- tetramethyl-1-(3-pyridylmethyl)anthra[2,1-d]pyrazol-3-yl]benzoic acid (55), all of which possess a 3-pyridylmethyl group at the five-membered ring nitrogen atom.