939402-75-2Relevant academic research and scientific papers
SAR studies on dihydropyrimidinone antibiotics
Xu, Lianhong,Zhang, Lijun,Jones, Robert,Bryant, Clifford,Boddeker, Nina,Mabery, Eric,Bahador, Gina,Watson, Julia,Clough, Jeffery,Arimilli, Murty,Gillette, Wendy,Colagiovanni, Dorothy,Wang, Keyu,Gibbs, Craig,Kim, Choung U.
, p. 1670 - 1674 (2011)
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing favorable selectivity were identified.
A facile construction of the 3,6-diamino-1,2,3,4-tetrahydropyridine-4-one scaffold: synthesis of N-3 to carbon replacement analog of TAN-1057A/B
Zhang, Lijun,Kim, Choung U.,Xu, Lianhong
, p. 3273 - 3275 (2008/02/02)
A facile construction of the 3,6-diamino-1,2,3,4-tetrahydropyridine-4-one class of compounds is described. Compound 2, a carbon analog at the N-3 position of TAN-1057A/B, was synthesized using this approach.
