939446-63-6Relevant academic research and scientific papers
Structure guided P1′ modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease
Monenschein, Holger,Horne, Daniel B.,Bartberger, Michael D.,Hitchcock, Stephen A.,Nguyen, Thomas T.,Patel, Vinod F.,Pennington, Lewis D.,Zhong, Wenge
, p. 3607 - 3611 (2012/07/17)
The synthesis and SAR of a series of BACE-1 hydroxyethyl amine inhibitors containing substitutions on a spirocyclobutyl moiety is described. Selectivity against cathepsin D, a related aspartyl protease with potential off target toxicity, and improved micr
