939658-27-2

Upstream product

• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 1122-91-4 4-bromo-benzaldehyde 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Facile one-pot green synthesis of 2-amino-4H-benzo[g]chromenes in aqueous ethanol under ultrasound irradiation

We report an efficient green one-pot approach for the synthesis of eighteen novel dihydro-4H-benzo[g]chromene derivatives under ultrasound irradiation conditions. The three-component condensation reaction proceeded through Knoevenagel-Michael reaction of

CeO2/CuO@N-GQDs@NH2 nanocomposite as a high-performance catalyst for the synthesis of benzo[g]chromenes

A three-component reaction of aromatic aldehydes, malononitrile or ethyl cyanoacetate and 2-hydroxy-1,4-naphthaquinone has been achieved in the presence of an amino-functionalized CeO2/CuO@ nitrogen graphene quantum dot nanocomposite as a highl

Synthesis of pyridinium-based salts: Catalytic application at the synthesis of six membered O-heterocycles

In this paper, a range of pyridinium-based ionic liquid (IL) and molten salts (MSs) with various counter ions were designed, synthesized and fully characterized. These novel ionic liquid and molten salts were prepared via the reaction of [PySO3

Application of cobalt phthalocyanine as a nanostructured catalyst in the synthesis of biological henna-based compounds

The present investigation describes synthesis of a good range of henna-based compounds in the presence of novel nano cobalt phthalocyanine like molten salt (tetra-2,3-pyridiniumporphyrazinato cobalt tribromomethanide) [Co (TPPABr)]CBr3 as an efficient, recyclable and thermally stable heterogeneous catalyst.

Synthesis and Biological Activity of Some Benzochromenoquinolinones: Tacrine Analogs as Potent Anti-Alzheimer's Agents

Alzheimer's disease (AD) is a well-known neurodegenerative disorder affecting millions of old people worldwide and the corresponding epidemiological data emphasize the importance of the disease. As AD is a multifactorial illness, various single target directed drugs that have reached clinical trials have failed. Therefore, various factors associated with outset of AD have been considered in targeted drug discovery. In this work, various benzochromenoquinolinones were synthesized and evaluated for their cholinesterase and BACE1 inhibitory activities as well as neuroprotective and metal-chelating properties. Among the synthesized compounds, 14-amino-13-(3-nitrophenyl)-2,3,4,13-tetrahydro-1H-benzo[6,7]chromeno[2,3-b]quinoline-7,12-dione (6m) depicted the best inhibitory activity toward acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.86 and 6.03 μm, respectively. Also, the compound could inhibit β-secretase 1 (BACE1) with IC50=19.60 μm and showed metal chelating ability toward Cu2+, Fe2+, and Zn2+. In addition, docking study demonstrated desirable interactions of compound 6m with amino acid residues characterizing AChE, BChE, and BACE1.

Amide-Troger's base derivative as well as synthesis method and application thereof

The invention provides an amide-Troger's base derivative as well as a synthesis method and application thereof. The structural formula of the amide-Troger's base derivative is one of the following formulas, and the amide-Troger's base derivative is synthe

Naphthoquinone and pyran derivative and synthetic method and application thereof

The invention discloses a naphthoquinone and pyran derivative and a synthetic method and an application thereof. A structural formula of the naphthoquinone and pyran derivative is as shown in the following formulas 7 or 9. The naphthoquinone and pyran der

Magnetite nanoparticles-supported APTES as a powerful and recoverable nanocatalyst for the preparation of 2-amino-5,10-dihydro-5,10-dioxo-4H-benzo[g]chromenes and tetrahydrobenzo[g]quinoline-5,10-diones

Aim and Objective: This study introduces a green and effective approach for the preparation of biologically-active heterocyclic compounds including 2-amino-5,10-dihydro-5,10-dioxo-4H-benzo[g]chromenes and tetrahydrobenzo[g]quinoline-5,10-diones using one-

Electrocatalytic one pot synthesis of medicinally relevant 4H-benzo[g]chromene and pyrano[2,3-g]chromene scaffold via multicomponent-domino approach

A highly efficient one pot, multicomponent synthesis of 4H-benzo[g]chromene and pyrano[2,3-g]chromene derivatives are reported by electrochemically stimulated condensation of an aromatic aldehyde, malononitrile and some enolizable acidic compounds in etha

One-pot synthesis of some 2-amino-4H-chromene derivatives using triethanolamine as a novel reusable organocatalyst under solvent-free conditions and its application in electrosynthesis of silver nanoparticles

A wide variety of 2-amino-4H-chromene derivatives with diverse substituents on the 4H-chromene ring were efficiently prepared via one-pot three-component reaction of an aromatic aldehyde and malononitrile with 2-hydroxynaphthalene-1,4-dione, ethyl acetoac