93968-81-1

Basic information

• Product Name: N-Butyryl Mesalazine
• Synonyms: N-Butyryl Mesalazine;2-Hydroxy-5-[(1-oxobutyl)aMino]benzoic Acid;N-Butyryl-5-ASA;MesalaMine Related CoMpound (N-Butyryl-5-AMinosalicylic Acid)
• CAS NO: 93968-81-1
• Molecular Formula: C11H13NO4
• Molecular Weight: 223.22522
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 93968-81-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: N-Butyryl Mesalazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Butyryl Mesalazine(93968-81-1)
• EPA Substance Registry System: N-Butyryl Mesalazine(93968-81-1)

Safety Data

• Hazardous Substances Data: 93968-81-1(Hazardous Substances Data)

Upstream product

• 106-31-0 butanoic acid anhydride 
• 89-57-6 5-Aminosalicylic Acid 
• 96-97-9 5-nitrosalicylic acid 
• 90922-94-4 methyl O-acetyl-5-aminosalicylate 
• 61294-22-2 methyl 2-acetoxy-5-nitrobenzoate 
• 17302-46-4 methyl 2-hydroxy-5-nitrobenzoate 
• 141-75-3 butyryl chloride 

Relevant articles and documents

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

A novel dual-prodrug carried by cyclodextrin inclusion complex for the targeting treatment of colon cancer

Background: There is an obvious correlation between ulcerative colitis and colorectal cancer, and the risk of colorectal cancer in patients with ulcerative colitis is increasing. Therefore, the combination therapy of anti-inflammatory and anti-tumor drugs may show promising to inhibit colon cancer. 5-aminosalicylic acid (5-ASA) with anti-inflammatory function is effective for maintaining remission in patients with ulcerative colitis and may also reduce colorectal cancer risk. Histone deacetylase (HDAC) plays an essential role in the progression of colon cancer. Butyric acid (BA) is a kind of HDAC inhibitor and thus shows tumor suppression to colon cancer. However, the volatile and corrosive nature of BA presents challenges in practical application. In addition, its clinical application is limited due to its non-targeting ability and low bioavailability. We aimed to synthesize a novel dual-prodrug of 5-ASA and BA, referred as BBA, to synergistically inhibit colon cancer. Further, based on the fact that folate receptor (FR) is over-expressed in most solid tumors and it has been identified to be a cancer stem cell surface marker in colon cancer, we took folate as the targeting ligand and used carboxymethyl-β-cyclodextrin (CM-β-CD) to carry BBA and thus prepared a novel inclusion complex of BBA/FA-PEG-CM-β-CD. Results: It was found that BBA/FA-PEG-CM-β-CD showed significant inhibition in cell proliferation against colon cancer cells SW620. It showed a pro-longed in vivo circulation and mainly accumulated in tumor tissue. More importantly, BBA/FA-PEG-CM-β-CD gave great tumor suppression effect against nude mice bearing SW620 xenografts. Conclusions: Therefore, BBA/FA-PEG-CM-β-CD may have clinical potential in colon cancer therapy. Graphical Abstract: [Figure not available: see fulltext.]

ACYLATED ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISORDERS

Disclosed herein are acylated active agents (e.g., acylated catechin polyphenols, acylated carotenoids, acylated mesalamines, acylated sugars, acylated shikimic acids, acylated ellagic acid, acylated ellagic acid analogue, and acylated hydroxybenzoic acids), active agent combinations (e.g., with a second agent that is a fatty acid) and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.