93969-13-2

Basic information

• Product Name: 6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester
• Synonyms: 6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester;6,7,8-trifluoro-1-(2-fluoroethyl)-4-keto-quinoline-3-carboxylic acid ethyl ester;6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-3-quinolinecarboxylic acid ethyl ester;ethyl 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxo-quinoline-3-carboxylate;ethyl 6,7,8-trifluoro-1-(2-fluoroethyl)-4-oxoquinoline-3-carboxylate
• CAS NO: 93969-13-2
• Molecular Formula: C14H11F4NO3
• Molecular Weight: 317.24
• Mol File: 93969-13-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester(93969-13-2)
• EPA Substance Registry System: 6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester(93969-13-2)

Safety Data

• Hazardous Substances Data: 93969-13-2(Hazardous Substances Data)

Usage

Uses

6,7,8-Trifluoro-1-(2-fluoroethyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid Ethyl Ester is used in preparation of Fluoro(quinolone)carboxylic Acids via amination of Alkyl Fluoro(haloquinolone)carboxylates with Amines.

Upstream product

• 383-50-6 2-fluoroethyl tosylate 
• 584-08-7 potassium carbonate 
• 79660-46-1 ethyl 6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 113220-16-9 ethyl 3-(2-fluoroethylamino)-2-(2,3,4, 5-tetrafluorobenzoyl) acrylate 

Relevant articles and documents

PROCESSES FOR PREPARING QUINOLONECARBOXYLATE DERIVATIVES

The present invention provides a process for preparing quinolonecarboxylate derivatives under a mild condition in high yield, so as to be favorably applied to a large-scale mass production thereof.

1-Substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids. New Quantitative Structure-Activity Relationships at N1 for the Quinolone Antibacterials

A series of 18 1-substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (N1 analogues of CI-934) was synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition.Correlations between the inhibition of DNA gyrase and antibacterial potency were established.A quantitative structure-activity relationship (QSAR) was derived by using the antibacterial potency of each of 11 strains of bacteria and the Gram-negative mean.The equations indicated that antibacterial potency was strongly dependent on STERIMOL length and width and the level of unsaturation of the N1 substituent.Some strains also showed a dependence on the presence of heteroatoms (O, N, S) in the N1 group.No significant correlations between gyrase inhibition and correlations of these parameters were found.These QSAR results are discussed in conjunction with the conformational analyses from molecular modeling studies.The substituent that most enhanced the activity of the quinolone in all regards was the cyclopropyl group.This analogue, 1-cyclopropyl-7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (PD 117558), demonstrated outstanding broad spectrum activity both in vitro and in vivo when compared to relevant standards.