939757-89-8

Basic information

• Product Name: 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester
• Synonyms: 1-(tert-Butoxycarbonyl)-4-phenylpyrrolidine-3-carboxylic acid;4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester;1-(boc)-4-phenylpyrrolidine-3-carboxylic acid
• CAS NO: 939757-89-8
• Molecular Formula: C16H21NO4
• Molecular Weight: 291.34
• Mol File: 939757-89-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 441.5 °C at 760 mmHg
• Flash Point: 220.8 °C
• Appearance: /
• Density: 1.196
• Storage Temp.: 2-8°C
• PKA: 4.31±0.40(Predicted)
• CAS DataBase Reference: 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester(939757-89-8)
• EPA Substance Registry System: 4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester(939757-89-8)

Safety Data

• Hazardous Substances Data: 939757-89-8(Hazardous Substances Data)

Usage

General Description

4-Phenyl-1,3-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester, also known as TMB-8, is a chemical compound used in biological and medical research. It is commonly used as a membrane-permeable inhibitor of the intracellular calcium release channels in cells, impacting the release of intracellular calcium stores and calcium influx. TMB-8 is also used to study the role of calcium in various physiological and pathological processes, such as cell signaling, muscle contraction, and neurotransmitter release. Additionally, it has been investigated for its potential therapeutic applications in treating conditions such as cardiovascular diseases and neurological disorders. TMB-8 is a versatile tool for investigating the role of calcium channels in cellular function and is a valuable compound in the field of pharmacology and biomedical research.

Upstream product

• 140148-70-5 (S)-1-N-boc-β-proline 
• 72925-16-7 (R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 199387-44-5 (4R)-4-benzyl-3-[(2E)-3-phenylprop-2-enoyl]-1,3-oxazolidin-2-one 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2140264-81-7 cis-1-tert-butyl 3-methyl 4-phenylpyrrolidine-1,3-dicarboxylate 
• 2140264-81-7 C₁₇H₂₃NO₄ 
• 951742-86-2 1-(tert-butoxycarbonyl)-4-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid 
• 80896-73-7 (+)-(3R,4R)-1-benzyl-4-phenyl-pyrrolidine-3-carboxylic acid 

Downstream Products

• 874367-19-8 C₁₂H₁₅NO₂*ClH 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS FOR MODULATING NR2F6

The present disclosure relates to compounds capable of modulating the activity of NR2F6. The compounds of the disclosure may be used in methods for the prevention and/or the treatment of diseases and disorders associated with modulating NR2F6 activity.

Process for the preparation of enantiomerically enriched cyclic beta-aryl or heteroaryl carbocyclic acids

The present invention relates to a process for the preparation of cis substituted cyclic β-aryl or heteroaryl carboxylic acid derivatives in high diastereo- and enantioselectivity by enantioselective hydrogenation in accordance with the following scheme w