939766-50-4

Basic information

• Product Name: C₁₉H₂₈N₂O₃
• CAS NO: 939766-50-4
• Molecular Weight: 332.443
• Mol File: 939766-50-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₈N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₈N₂O₃(939766-50-4)
• EPA Substance Registry System: C₁₉H₂₈N₂O₃(939766-50-4)

Safety Data

• Hazardous Substances Data: 939766-50-4(Hazardous Substances Data)

Upstream product

• 42419-59-0 1-(morpholin-4-yl)cyclohexanecarbonitrile 
• 64269-03-0 (1-morpholinocyclohexyl)methanamine 
• 21615-34-9 2-Methoxybenzoyl chloride 
• 108-94-1 cyclohexanone 

Relevant articles and documents

Discovery of a novel series of selective HCN1 blockers

The discovery of a series of novel, potent, and selective blockers of the cyclic nucleotide-modulated channel HCN1 is disclosed. Here we report an SAR study around a series of selective blockers of the HCN1 channel. Utilization of a high-throughput VIPR assay led to the identification of a novel series of 2,2-disubstituted indane derivatives, which had moderate selectivity and potency at HCN1. Optimization of this hit led to the identification of the potent, 1,1-disubstituted cyclohexane HCN1 blocker, 2-ethoxy-N-((1-(4- isopropylpiperazin-1-yl)cyclohexyl)methyl)benzamide. The work leading to the discovery of this compound is described herein.