93982-06-0

Usage

Uses

Used in Pharmaceutical Applications:
(R)-glycolic acid, compound with [S-(R,S)]-2-(methylamino)-1-phenylpropanol(1:1) is used as a therapeutic agent for its potential synergistic effects on anti-inflammatory and analgesic properties. The combination of these two compounds may enhance their individual benefits, providing a more effective treatment for pain and inflammation.
Used in Skincare Applications:
In the skincare industry, (R)-glycolic acid, compound with [S-(R,S)]-2-(methylamino)-1-phenylpropanol(1:1) is used as an exfoliating and moisturizing agent. The combination of these compounds may offer enhanced skincare benefits, such as improved skin texture, reduced appearance of fine lines and wrinkles, and increased hydration.
Used in Cosmetic Formulations:
(R)-glycolic acid, compound with [S-(R,S)]-2-(methylamino)-1-phenylpropanol(1:1) is used as an active ingredient in cosmetic formulations to provide anti-inflammatory and analgesic effects, as well as to improve skin health and appearance. The synergistic action of these compounds may lead to more effective skincare products with multiple benefits.

Upstream product

• 321-98-2 (1S,2R)-(+)-ephedrine 
• 611-71-2 (R)-Mandelic Acid 

Downstream Products

• 321-98-2 (1S,2R)-(+)-ephedrine 
• 611-71-2 (R)-Mandelic Acid 

Relevant academic research and scientific papers

Chiral Discrimination in the Structures and Energetics of Association of Stereoisomeric Salts of Mandelic Acid with α-Phenethylamine, Ephedrine, and Pseudoephedrine

A careafully coordinated study of the relations between structure and energetics of association in the crystalline state and solution is reported here.Hydrogen-bonded ion pairs formed from reaction between the enantiomers of mandelic acid, α-phenethylamine, ephedrine, and pseudoephedrine have been studied in dimethyl sulfoxide, dioxane, and water and as solid salts.Single-crystal X-ray analysis, performed on four unique diastereomeric pairs of (+/-)-ephedrinium and (+/-)-pseudoephedrinium (+/-)-mandelates yielded details of the solid-state hydrogen-bonding schemes for all eight diastereomeric salts. 1H NMR spectra (at 300 and 600 MHz) over a wide concentration range were determined and indicated a simple two-state equilibrium between ion pairs and free ions in dimethyl sulfoxide.The dissociation equilibria in dimethyl sulfoxide were examined more quantitatively by conductance and the results treated by the Fuoss-Justice, Fuoss-1977, and Onsager methods to yield calculated dissociation constants, equivalent conductances, and mean activity coefficients over a wide concentration range.Thermochemical properties determined by various techniques were (1) the heat of fusion by differential scanning calorimetry, (2) heats of solution of the crystalline salts to high dilution by isoperibolic batch calorimetry, and (3) heats of protonation and heats of dissociation from thermometric titration of solutions of mandelic acid with the bases.Extensive use was made of cross-chiral checks (e.g., R,R' vs S,S') to prove that observed chiral discrimination factors were real and accurate.Significant chiral discrimination factors were found for all properties of diastereomeric combinations.In several cases the largest differences in thermochemical properties and 1H NMR spectra of diastereomeric pairs could be related reasonably to differences in hydrogen-bonding schemes in their crystals.