93985-81-0

Basic information

• Product Name: Benzenesulfonamide, N-(2-oxo-2-phenylethyl)-
• CAS NO: 93985-81-0
• Molecular Formula: C14H13NO3S
• Molecular Weight: 275.328
• Mol File: 93985-81-0.mol

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-(2-oxo-2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-(2-oxo-2-phenylethyl)-(93985-81-0)
• EPA Substance Registry System: Benzenesulfonamide, N-(2-oxo-2-phenylethyl)-(93985-81-0)

Safety Data

• Hazardous Substances Data: 93985-81-0(Hazardous Substances Data)

Upstream product

• 74427-60-4 1-(phenylsulphonylamino)acetyl chloride 
• 71-43-2 benzene 
• 1666-16-6 N-benzylidene-N'-benzenesulfonylhydrazone 
• 70-11-1 α-bromoacetophenone 
• 80-17-1 benzenesufonyl hydrazide 
• 19871-46-6 1-Benzenesulfonyl-2-phenyl-aziridine 
• 98-10-2 benzenesulfonamide 
• 536-74-3 phenylacetylene 

Downstream Products

• 109450-87-5 N-(1-hydroxymethyl-2-oxo-2-phenyl-ethyl)-benzenesulfonamide 
• 56157-02-9 N-methyl-N-phenacyl-benzenesulfonamide 

Relevant articles and documents

Regioselective Hydroperoxylation of Aziridines and Epoxides Only with Aqueous Hydrogen Peroxide

A catalyst and organic solvent-free regioselective hydroperoxylation of aziridines and epoxides, including spiroaziridine- and spiroepoxy oxindoles have been explored with commercially available 50% aq. H2O2. This method provides an access to secondary benzylic β-hydroperoxy amines and -alcohols and tertiary 3-hydroperoxy oxindoles. The protocol is also applicable to the less reactive alkyl aziridines. Furthermore, an acid-catalyzed Kornblum-DeLaMare type rearrangement of secondary benzylic hydroperoxide has also been revealed to afford amino- and hydroxyl ketones. (Figure presented.).

Metal-Free Amidation Reactions of Terminal Alkynes with Benzenesulfonamide

A novel and efficient approach has been developed to synthesize α-sulfonylamino ketones through the reaction between terminal alkynes and sulfonamides under ambient air using PIDA (diacetoxy iodobenzene). A library of α-sulfonylamino ketone derivatives having a variety of substituents has been synthesized. A plausible reaction pathway has been predicted. This reaction offers a broad substrate scope, metal-free synthesis, excellent regioselectivity, easily accessible reactants, and room temperature reaction conditions under ambient air and is operationally simple. A gram-scale synthesis demonstrates the potential applications of the present method. In addition, we have also synthesized α-acetoxy ketones in the case of absence of sulfonamide.

2-Methylquinoline promoted oxidative ring-opening of N-sulfonyl aziridines with DMSO: facile synthesis of α-amino aryl ketones

2-Methylquinoline promoted room-temperature oxidative ring-opening of N-sulfonyl aziridines with DMSO has been developed, providing a mild and convenient method for the synthesis of a variety of different N-sulfonyl protected α-amino aryl ketones. The employment of 2-methylquinoline was crucial for the success of this mild transformation and good to excellent yields could be achieved.

Base-catalyzed N -N bond cleavage of hydrazones: Synthesis of α-amino ketones

An efficient Cs2CO3-promoted synthesis of α-amino ketones using hydrazines, aldehydes, and α-haloketones as starting materials through a cascade condensation/nucleophilic substitution/N -N bond cleavage route is developed. The carbonyl group plays a key role in this novel N -N bond cleavage process. Breaking good: A novel method of base-catalyzed N -N bond cleavage of hydrazones has been discovered. A variety of α-amino ketones was synthesized using hydrazines, α-haloketones, and benzaldehyde as starting materials through a cascade condensation/ nucleophilic substitution/N -N bond cleavage sequence.