93986-80-2Relevant academic research and scientific papers
MDM2-HDAC double-target inhibitor, medicinal composition and preparation and application of MDM2-HDAC double-target inhibitor
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Paragraph 0207-0209, (2018/12/14)
The invention provides a MDM2-HDAC double-target inhibitor, a medicinal composition and preparation and application of the MDM2-HDAC double-target inhibitor. The MDM2-HDAC double-target inhibitor hasa structure as shown in formula I. The inhibitor with th
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development
Ding, Qingjie,Zhang, Zhuming,Liu, Jin-Jun,Jiang, Nan,Zhang, Jing,Ross, Tina M.,Chu, Xin-Jie,Bartkovitz, David,Podlaski, Frank,Janson, Cheryl,Tovar, Christian,Filipovic, Zoran M.,Higgins, Brian,Glenn, Kelli,Packman, Kathryn,Vassilev, Lyubomir T.,Graves, Bradford
supporting information, p. 5979 - 5983 (2013/08/23)
Restoration of p53 activity by inhibition of the p53-MDM2 interaction has been considered an attractive approach for cancer treatment. However, the hydrophobic protein-protein interaction surface represents a significant challenge for the development of s
N-SUBSTITUTED PYRROLIDINES
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Page/Page column 11, (2012/01/15)
Compounds of formula and enantiomers and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceu
