939983-46-7

Upstream product

• 273381-75-2 3-(3-methoxy-phenyl)-3-methyl-butan-2-one 
• 76106-60-0 1,1-dimethyl-4-phenyl-1-(3-tetrahydropyranyloxyphenyl)but-3-en-2-one 
• 76106-61-1 1-(3-hydroxyphenyl)-1,1-dimethyl-4-phenylbut-3-en-2-one 

Downstream Products

• 939983-48-9 3-(3-ethoxy-phenyl)-3-methyl-butan-2-one 

Relevant academic research and scientific papers

4,4,5,5, Tetrasubstituted imidazolines

There is provided a compound of formula I and the pharmaceutically acceptable salts and esters thereof wherein X1, X2, R1, R2, R3, R4, R5 and R6 are herein described. The compounds exhibit activity as anticancer agents.

Intramolecular Alkylation of Phenols. Part 4. Base-catalysed Cyclisation of Phenolic Enones. Scope and Limitations

The phenolic enones (4), (5), (8), (9), and (13) cyclise readily under acidic conditions.However, neither these nor the thio-substituted phenols (11a), (13a), (14a), and (15a) closed under basic conditions.Involvement of unfavourable equilibria is disproved.Comparison is made with related successful cyclisations of the saturated ketone (38) and aldehyde (39).Preliminary results suggest that strict stereo-electronic requirements are necessary for enone ring closure and that these conditions are not met in base-catalysed 5-Endo- and 6-Endo-Trigonal ring closures of the phenols of general type (2; n=0 and n=1).