939985-83-8

Upstream product

• 74516-59-9 2-<2-Benzyloxy-5-methoxy-phenyl>-aethylamin 
• 29969-31-1 2-Benzyloxy-5-methoxy-β-nitro-styrol 
• 56979-57-8 2-benzyloxy-5-methoxybenzaldehyde 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 

Downstream Products

• 939985-84-9 N-(tert-butoxycarbonyl)-2-[2-(3-butynyl-1-oxy)-5-methoxyphenyl]ethylamine 
• 939985-85-0 5-{4-[2-(2-(tert-butoxycarbonylamino)ethyl)-4-methoxyphenoxy]but-1-ynyl}-5'-O-benzoyl-2',3'-didehydro-2',3'-dideoxyuridine 
• 939985-86-1 5-{4-[(2-((5-bromo-2-pyridinyl)aminothiocarbonylamino)-ethyl)-4-methoxyphenoxy]but-1-ynyl}-5'-O-benzoyl-2',3'-didehydro-2',3'-dideoxyuridine 
• 1101872-56-3 N-(tert-butoxycarbonyl)-2-{5-methoxy-2-[2-(2-p-toluenesulfonyloxyethoxy)ethoxy]phenyl}ethylamine 
• 1101872-55-2 N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(2-p-toluenesulfonyloxyethoxy)phenyl]ethylamine 
• 1101872-45-0 N-(tert-butoxycarbonyl)-2-[2-(2-butynyl-1-oxy)-5-methoxyphenyl]ethylamine 
• 1101872-44-9 N-(tert-butoxycarbonyl)-2-[5-methoxy-2-(4-pentynyl-1-oxy)phenyl]ethylamine 
• 1101872-46-1 N-(tert-butoxycarbonyl)-2-(2-allyloxy-5-methoxyphenyl)ethylamine 
• 1101872-41-6 N-(tert-butoxycarbonyl)-2-(5-methoxy-2-propoxyphenyl)ethylamine 
• 1101872-50-7 N-(tert-butoxycarbonyl)-2-(2-methoxycarbonylmethyloxy-5-methoxyphenyl)ethylamine 
• 1101872-51-8 N-(tert-butoxycarbonyl)-2-(2-cyanomethoxy-5-methoxyphenyl)ethylamine 
• 1101872-52-9 N-(tert-butoxycarbonyl)-2-[2-(3-cyanopropyloxy)-5-methoxyphenyl]ethylamine 
• 939985-82-7 N-(tert-butoxycarbonyl)-2-(2-benzyloxy-5-methoxyphenyl)ethylamine 
• 1101872-47-2 N-(tert-butoxycarbonyl)-2-[2-(2-benzyloxyethoxy)-5-methoxyphenyl]ethylamine 

Relevant academic research and scientific papers

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

The synthesis of bifunctional compound 10 consisting of d4U joined at C-5 to a butynyl spacer attached to HI-236 is reported using a Sonogashira coupling as a key step. As a non-cleavable bifunctional HIV inhibitor incorporating an NRTI with an NNRTI, 10 shows good inhibitory activity (EC50 = 250 nM) against HIV (IIIB) replication in MT-2 cell culture, which is eight times greater than that of d4T and between those of the two component drugs.