940002-59-5

Basic information

• Product Name: Sitagliptin Carbamoyl -D-Glucuronide
• Synonyms: Sitagliptin Carbamoyl -D-Glucuronide;1-[N-[(1R)-3-[5,6-Dihydro-3-(trifluoroMethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)Methyl]propyl]carbaMate];Sitagliptin CarbaMoyl β-D-Glucuronide SodiuM Salt;beta-D-Glucopyranuronic acid 1-[N-[(1R)-3-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-3-oxo-1-[(2,4,5-trifluorophenyl)methyl]propyl]carbamate]
• CAS NO: 940002-59-5
• Molecular Formula: C23H23F6N5O9
• Molecular Weight: 627.449
• Product Categories: Bases & Related Reagents;Inhibitors;Intermediates & Fine Chemicals;Metabolites & Impurities;Nucleotides;Pharmaceuticals
• Mol File: 940002-59-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 167-169°C (dec.)
• Appearance: /
• Density: 1.844g/cm³
• Refractive Index: 1.649
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Methanol, Water
• CAS DataBase Reference: Sitagliptin Carbamoyl -D-Glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: Sitagliptin Carbamoyl -D-Glucuronide(940002-59-5)
• EPA Substance Registry System: Sitagliptin Carbamoyl -D-Glucuronide(940002-59-5)

Safety Data

• Hazardous Substances Data: 940002-59-5(Hazardous Substances Data)

Usage

Description

Sitagliptin Carbamoyl -D-Glucuronide is a metabolite of Sitagliptin, a medication used for the treatment of type 2 diabetes. It is formed through the metabolism of Sitagliptin in the body and has been identified as a key component in the drug's therapeutic effects.

Uses

Used in Pharmaceutical Industry:
Sitagliptin Carbamoyl -D-Glucuronide is used as a metabolite of Sitagliptin for the treatment of type 2 diabetes. It plays a crucial role in the drug's mechanism of action, helping to improve glycemic control and reduce blood sugar levels in patients with diabetes.
Used in Research and Development:
Sitagliptin Carbamoyl -D-Glucuronide is used as a research tool for studying the pharmacokinetics, metabolism, and efficacy of Sitagliptin. It helps researchers understand the drug's absorption, distribution, metabolism, and excretion in the body, as well as its potential side effects and drug interactions.
Used in Quality Control and Standardization:
Sitagliptin Carbamoyl -D-Glucuronide is used as a reference compound for the quality control and standardization of Sitagliptin-containing pharmaceutical products. It ensures that the drug meets the required specifications and maintains a consistent level of quality, safety, and efficacy.
Used in Drug Metabolism Studies:
Sitagliptin Carbamoyl -D-Glucuronide is used in drug metabolism studies to investigate the metabolic pathways and enzymes involved in the biotransformation of Sitagliptin. This information is valuable for optimizing drug dosing regimens, predicting potential drug-drug interactions, and assessing the safety and efficacy of the medication in different patient populations.

InChI:InChI=1/C23H23F6N5O9/c24-10-6-12(26)11(25)4-8(10)3-9(30-22(41)43-20-17(38)15(36)16(37)18(42-20)19(39)40)5-14(35)33-1-2-34-13(7-33)31-32-21(34)23(27,28)29/h4,6,9,15-18,20,36-38H,1-3,5,7H2,(H,30,41)(H,39,40)/t9-,15-,16-,17-,18?,20-/m1/s1