94006-05-0Relevant academic research and scientific papers
METHOD FOR THE SYNTHESIS OF GLYCOCHOLIC ACID
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Page/Page column 4-5, (2010/11/18)
Process for preparing glycocholic acid comprising the following steps: a) making a mixed anhydride of cholic acid through the suspension of cholic acid in acetone or in aqueous acetone in presence of a base, and subsequent reaction with an alkyl chloroformate; b) aminolysis of the so obtained mixed anhydride of cholic acid with an aqueous solution of a glycine ester, resulting in an ester of glycocholic acid; c) hydrolysis of the ester of glycocholic acid thus obtained through the treatment with aqueous soda or aqueous potassium and precipitation of glycocholic acid through acidification of the corresponding sodium salt.
Chemical modifications of bile acids under high-intensity ultrasound or microwave irradiation
Cravotto, Giancarlo,Boffa, Luisa,Turello, Marta,Parenti, Massimo,Barge, Alessandro
, p. 77 - 83 (2007/10/03)
High-intensity ultrasound (HIU) and microwave (MW) irradiation, having emerged as effective promoters of organic reactions, were exploited for the synthesis of bile acids derivatives. Esterification, amidation, hydrolysis, oxidation, and reduction were investigated. Compared to conventional methods, both techniques proved much more efficient, increasing product yields and dramatically cutting down reaction times. Scaled-up studies are now under way.
Synthesis of linear and cyclic dimeric ester derivatives from bile acids and glycine
Tian, Ze,Cui, Hong,Wang, Yan
, p. 3821 - 3829 (2007/10/03)
Two novel taylor-made linear and cyclic dimers were synthesized from the inexpensive steroid bile acids and amino acid glycine. The structures and stereochemistry of all intermediates and dimers were determined by means of spectroscopic analyses.
