940315-37-7

Basic information

• Product Name: N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-methyl-tetrahydrofuran-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide
• CAS NO: 940315-37-7
• Molecular Weight: 361.373
• Mol File: 940315-37-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-methyl-tetrahydrofuran-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-methyl-tetrahydrofuran-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide(940315-37-7)
• EPA Substance Registry System: N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-methyl-tetrahydrofuran-2-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide(940315-37-7)

Safety Data

• Hazardous Substances Data: 940315-37-7(Hazardous Substances Data)

Upstream product

• 940315-26-4 5-hydroxy-1-methyl-2-(2-methyl-tetrahydro-furan-2-yl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester 
• 140-75-0 para-fluorobenzylamine 
• 940315-25-3 5-ethoxycarbonylmethyl-2-methyl-3-(2-methyl-tetrahydro-furan-2-yl)-2,5-dihydro-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester 
• 19679-75-5 cyano-2 methyl-2 tetrahydrofuranne 

Relevant articles and documents

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors

Integration of viral DNA into the host cell genome is an obligatory process for successful replication of HIV-1. Integrase catalyzes the insertion of viral DNA into the target DNA and is a validated target for drug discovery. Herein, we report the synthesis, antiviral activity and pharmacokinetic profiles of several C2-carbon-linked heterocyclic pyrimidinone-4-carboxamides that inhibit the strand transfer step of the integration process.