94033-94-0Relevant academic research and scientific papers
Efficient synthesis of various 4-tosyloxy-2-substituted phenols using pyridinium salt-supported [hydroxy(tosyloxy)iodo]benzene reagent
Yang, Bing,Zhang, Jizhen,Zhao, Dejian,Wang, Yazhen,Jia, Hongbin
supporting information, p. 930 - 932 (2013/09/02)
A novel pyridinium salt-supported [hydroxy(tosyloxy)-iodo]benzene (HTIB) reagent (N-{4-[hydroxy(tosyloxy)iodo]-phenyl}pyridinium hexafluorophosphate) was prepared via Zincke's reaction. The conjugated HTIB was an effective reagent for tosyloxylation of phenolic aromatic rings with an electron-withdrawing substitute at the ortho-position. The reagent can be easily regenerated in high yield and reused three times without any decrease in activity.
The synthesis of 4-tosyloxy-2-substituted phenols using new solid pyridinium salt supported [hydroxyl(tosyloxy)iodo]benzene reagents
Yang, Bing,Zhang, Jizhen,Zhao, Dejian,Kuang, Hua
, p. 293 - 295 (2012/10/08)
Two new solid pyridinium salt supported HTIB reagents (N-{4- [hydroxyl(tosyloxy)iodo]benzyl}pyridinium tetrafluoroborate and N-{4-[hydroxyl(tosyloxy)iodo]phenylcarbamoylmethyl}pyridinium tetrafluoroborate) were synthesised using a pyridinium salt as a cat
NOVEL COMPOUNDS
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Page/Page column 58, (2011/04/25)
The present invention discloses novel compounds inhibiting LRRK2 kinase activity, the preparation processes thereof, the compositions containing them, as well as the use in treating diseases characterized by LRRK2 kinase activity, particularly Parkinson's disease and Alzheimer's disease.
The Regioselective Cleavage of Aryl Tosylates by Electrochemical Reduction
Civitello, Edgar R.,Rapoport, Henry
, p. 834 - 840 (2007/10/02)
The electrochemical reductions of eight bis(tosyloxy)benzenoid compounds were studied as a method for the regioselective cleavage of aryl tosylates.For the methyl bis(tosyloxy)benzoate isomers, a strong preference was observed for cleavage of the tosyl group in conjugation with the electron-withdrawing ester moiety.Thus it was possible to selectively cleave tosyl groups to the ortho or para positions over tosyl groups at the meta positions.The bis(tosyloxy)anisole isomers displayed the opposite regioselectivity favoring cleavage of tosyl groups that were meta to the electron-donating methoxy substituent.The general electrochemical process for the reduction of aryl tosylates has been shown to be selective, high yielding, and reproducible on gram quantities.
A New Regiospecific Synthesis of 1,4-Dihydroxyxanthones
Simoneau, Bruno,Brassard, Paul
, p. 1507 - 1510 (2007/10/02)
Several methyl salicylates have been found to substitute halogenated benzoquinones regiospecifically in the presence of anhydrous potassium fluoride.The resultant phenoxybenzoquinones were reduced and cyclized to highly functionalized xanthones of unambig
