94042-08-7

Basic information

• Product Name: Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dinitrate
• Synonyms: Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dinitrate;DACH platinuM dinitrate
• CAS NO: 94042-08-7
• Molecular Formula: C6H14N2O2Pt+2
• Molecular Weight: 341.26556
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 94042-08-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >300°C (dec.)
• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Methanol (Very Slightly. Heated), Water (Very Slightly. Heated)
• CAS DataBase Reference: Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dinitrate(CAS DataBase Reference)
• NIST Chemistry Reference: Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dinitrate(94042-08-7)
• EPA Substance Registry System: Diaquo[(1R,2R)-1,2-cyclohexanediamine]platinum Dinitrate(94042-08-7)

Safety Data

• Hazardous Substances Data: 94042-08-7(Hazardous Substances Data)

Usage

Chemical Properties

Beige Solid

Uses

Oxaliplatin (O845075) intermediate as anti-cancer therapeutic agent and dual therapeutic/imaging contrast agent.

Upstream product

• 38780-40-4 {(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) 
• 7732-18-5 water 

Relevant articles and documents

Novel platinum(II) complexes containing diaminocyclohexane and thiourea derivative ligands: Synthesis and X-ray crystal structure of (trans-1,2-diaminocyclohexane)dithioureaplatinum(II) nitrate monohydrate

Six novel platinum(II) complexes of the form [Pt(dach)L2] (NO3)2, where dach = trans-1,2-diaminocyclohexane, L = thiourea (tu) or its derivatives, including 1-acetyl-2-thiourea, 1-ethyl-2-thiourea, 2-imidazolidinethione, 1,3-dimethyl-2-thiourea and 1,1,3,3-tetramethyl-2-thiourea, have been synthesized and characterized by elemental analysis, IR spectrometry, and NMR (1H and 13C) spectroscopy. The general synthetic procedure involves the reaction of [Pt(dach)(H2O)2](NO3)2, which is formed in situ by treating Pt(dach)I2 with silver nitrate, and two equivalents of tu or its derivatives. All the complexes are ionic compounds with nitrate counter ions and thus water soluble. The crystal structure of [Pt(dach)(tu)2](NO3)2·H2O is determined using a single crystal X-ray diffraction method. This compound crystallizes in the orthorhombic space group Pnma with centrosymmetry.

Process for the preparation of 1,2-diaminocyclohexane-platinum(II) complexes

A process for the preparation of diaminocyclohexane-platinum(II)-dicarboxylates has the following steps: B Conversion of K2PtX2 with 1,2-diaminocyclohexane (DACH) to (2): C Conversion of (2) with too little quantity of silver salt AgnA to (3): and removal of the resulting AgX precipitate. D Conversion of (3) with a dicarboxylate to (1): F Isolation of the product (1), wherein R1 and R2 together form a dicarboxylato group, X stands for Cl or I, A for a 1-2-valent anion of a mineral acid, and n stands for 1 or 2.