94066-69-0Relevant academic research and scientific papers
Functionalization of benzylic Sp3 C-H of 2-methylazaarenes in deep eutectic solvent
Chen, Guo-Qing,Xie, Zong-Bo,Ai, Feng,Chen, Zhong-Sheng,Lan, Jin,Hu, Zhi-Yu,Le, Zhang-Gao
, p. 1189 - 1199 (2019/12/23)
The catalyst-free addition of 2-methylazaarene benzylic sp3 C-H to electron-deficient olefins in deep eutectic solvents is reported. Moderate to good yields were obtained in 2 h at 80 °C in deep eutectic solvents. The method was operationally e
Benzylic SP3 c-h functionalization reaction of 2-methylazaarenes catalyzed by pepsin
Ai, Feng,Chen, Guo-Qing,Ji, Jiu-Jian,Zhu, Zhi-Qiang,Le, Zhang-Gao,Xie, Zong-Bo
, p. 1410 - 1420 (2018/08/29)
In this work, the addition of 2-methylazaarenes benzylic sp3 C-H to electron-deficient olefins, catalyzed by pepsin from pig gastric mucosa was reported. A series of azaarene derivatives (1 mmol) were obtained in good yields at 60 °C for 60～72 h with 20 mg pepsin as catalyst. This is a facile method and the reaction conditions are mild, which expands the application of biocatalysis in sp3 C-H functionalization of azaarenes.
