940696-89-9

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 926583-68-8 N-(2-iodophenyl)-2,5-dimethoxybenzamide 
• 1313853-18-7 C₁₇H₁₈O₅S 
• 1204-21-3 2-bromo-2',5'-dimethoxyacetophenone 
• 615-43-0 2-iodophenylamine 

Downstream Products

• 1602748-19-5 methyl 2-(2-(2,5-dimethoxyphenyl)-1H-benzo[d]imidazol-1-yl)acetate 

Relevant academic research and scientific papers

New highly fluorescent silver complexes and their thin films obtained by spin coating method

New silver complexes with ligands obtained from 2(2-pirydyl)ethylamine (epy) or o-phenylenediamine and series of aldehydes were obtained and characterized by their crystalline, molecular and spectroscopic (UV-Vis, fluorescence, IR, NMR) features. Molecula

A facile and efficient synthesis of benzimidazole as potential anticancer agents

Abstract: This study reports a simple process to synthesize and separate of 2-(substituted-phenyl) benzimidazole derivatives with high yield and efficiency. Specifically, by reacting ortho-phenylenediamines with benzaldehydes using sodium metabisulphite a

A Zn based metal organic framework as a heterogeneous catalyst for C-C bond formation reactions

Herein, we report the synthesis and application of a Zn-Bp-BTC MOF (Bp-4,4′-bipyridine; BTC-1,3,5-benzene tricarboxylic acid; MOF-metal organic framework) as a heterogeneous catalyst for mediating organic reactions. Initially, conditions were optimized for the Knoevenagel condensation reaction using Zn-Bp-BTC as a heterogeneous catalyst by varying the solvent, temperature and catalyst loading. Although the reaction proceeded at room temperature using methanol as the solvent, 60 °C offered the best yield in a shorter duration. Under optimized reaction conditions, a wide range of α,β-unsaturated dicyano compounds were prepared from the corresponding carbonyl precursor and malononitrile, the active methylene counterpart. Systematic investigation was also carried out to assess the role of the ligand and metal salt in the Knoevenagel condensation reaction. It was found that the Zn-Bp-BTC MOF catalyzed the reaction efficiently in comparison to its analogue Zn-BTC MOF and precursor Zn(NO3)2·6H2O. Finally, catalytic recycling and stability studies showed that the catalyst is able to mediate the reaction for up to five consecutive cycles without undergoing any significant chemical or morphological changes. Further, the catalyst was tested for its efficacy in a multi-component reaction (MCR). A MCR with the Zn-Bp-BTC MOF as the catalyst afforded good yields and there was no reaction in the absence of the catalyst. Similarly, the catalyst was tested for its efficiency in benzimidazole synthesis.

A modern and practical laccase-catalysed route suitable for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles

Heterocyclic aromatic compounds containing an imine (C═N) bond such as benzimidazoles and benzothiazoles are important active pharmaceutical ingredients. The synthesis of 2-aryl-1H-benzimidazoles and 2-arylbenzothiazoles in good to excellent yields was ac

MIL-101(Fe) hexagonal microspindle as a highly efficient, reusable and versatile catalyst for benzo-fused heterocyclic nucleus synthesis

A highly reusable, efficient and versatile MIL-101(Fe) catalyst was prepared and characterized using various techniques including Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy and energy-dispersive X-ray spectroscopy. This heterogeneous catalyst demonstrated a promising activity for condensation/cyclization reactions of various aryl aldehydes with 1,2-phenylenediamine or 2-aminothiophenol. The corresponding benzo-fused heterocyclic products were generated in good to excellent yields under mild conditions in the presence of the catalyst. In addition, the catalyst can be easily separated and reused in eight consecutive runs with consistent catalytic activity.

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

Chromium(III)-salen complex nanoparticles on AlPO4: as an efficient heterogeneous and reusable nanocatalyst for mild synthesis of highly functionalized piperidines, 2-arylbenzimidazoles, and 2-arylbenzothiazoles

Abstract: A simple, convenient, and highly efficient multicomponent one-pot synthesis of highly functionalized piperidines has been developed via tandem reactions of β-keto esters, aromatic aldehydes, and various amines in ethanol at room temperature using catalytic amount (10?mol%) of a chromium(III)-salen complex nanoparticles supported on AlPO4. The heterogeneous catalyst exhibited excellent activity and reusability (up to 8 times) in the synthesis of highly functionalized piperidines. Also, synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles have been efficiently developed under mild condition from o-phenylenediamines or 2-aminothiophenol with aryl aldehydes via one-step process using catalytic amount (2.0?mol%) of nanocatalyst in air atmosphere as a green oxidant. The heterogeneous catalyst was characterized by scanning electron microscopy, atomic force microscopy, inductively coupled plasma spectrometry, thermogravimetry for analysis of nitrogen adsorption, and FT-IR spectroscopy. Graphical Abstract: [Figure not available: see fulltext.].

Facile one-pot clean synthesis of benzimidazole motifs: Exploration on bismuth nitrate accelerated subtle catalysis

Abstract In the present letter, an efficient, clean and one-pot synthesis of 2-substituted benzimidazole and 1,2-disubstituted benzimidazole derivatives has been explored by reacting o-phenylenediamine with aromatic aldehydes using bismuth nitrate as a ca

Design, synthesis, biological evaluation and binding mode modeling of benzimidazole derivatives targeting the cannabinoid receptor type 1

A series of N-acyl-2,5-dimethoxyphenyl-1H-benzimidazoles were designed based on a CoMFA model for cannabinoid receptor type 1 (CB1) ligands. Compounds were synthesized and radioligand binding affinity assays were performed. Eight novel benzimidazoles exhibited affinity for the CB1 receptor in the nanomolar range, and the most promising derivative compound 5 displayed a Ki value of 1.2 nM when compared to CP55,940. These results confirm our previously reported QSAR model on benzimidazole derivatives, providing new information for the development of small molecules with high CB1 affinity.

Synthesis of 2-arylbenzimidazole analogues

Substituted 2-arylbenzimidazoles (4) were easily synthesized in good yields starting from the condensation reaction of 1,2-diaminobenzenes (1) with β-ketosulfones (5) in the presence of boiling HOAc.