94071-17-7

Basic information

• Product Name: 6-(4-methylbenzoyl)pyridine-2-carbaldehyde
• Synonyms: 6-(4-methylbenzoyl)pyridine-2-carbaldehyde;6-(4-Methylbenzoyl)-2-pyridinecarbaldehyde
• CAS NO: 94071-17-7
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.24264
• EINECS: 301-817-8
• Mol File: 94071-17-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 406.6°C at 760 mmHg
• Flash Point: 201.9°C
• Appearance: /
• Density: 1.193g/cm³
• Vapor Pressure: 8.01E-07mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 6-(4-methylbenzoyl)pyridine-2-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-methylbenzoyl)pyridine-2-carbaldehyde(94071-17-7)
• EPA Substance Registry System: 6-(4-methylbenzoyl)pyridine-2-carbaldehyde(94071-17-7)

Safety Data

• Hazardous Substances Data: 94071-17-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H11NO2/c1-10-5-7-11(8-6-10)14(17)13-4-2-3-12(9-16)15-13/h2-9H,1H3

Upstream product

• 112498-15-4 6-(4-methylbenzyl)-2-methylpyridine 
• 108-48-5 2,6-dimethylpyridine 

Relevant articles and documents

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen

The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP-MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.