94073-27-5Relevant academic research and scientific papers
Iron dienylphosphate tricarbonyl complexes as water-soluble enzyme-triggered CO-releasing molecules (ET-CORMs)
Romanski, Steffen,Ruecker, Hannelore,Stamellou, Eleni,Guttentag, Miguel,Neudoerfl, Joerg-Martin,Alberto, Roger,Amslinger, Sabine,Yard, Benito,Schmalz, Hans-Guenther
, p. 5800 - 5809 (2012)
A series of racemic phosphoryloxy-substituted (η4- cyclohexadiene)Fe(CO)3 complexes was synthesized by exploiting the O-phosphorylation of (dienol)Fe(CO)3 intermediates generated in situ from the corresponding triisopropylsiloxy-protected complexes. The phosphorylated products were fully characterized by spectroscopic methods, including single-crystal X-ray diffraction in four cases. Monodeprotection of two dimethyl phosphate derivatives with trimethylamine led to the tetramethylammonium salts of the (cyclohexadienyl methyl phosphate)Fe(CO) 3 complexes. These compounds are the first water-soluble enzyme-trigged CO-releasing molecules (ET-CORMs). The phosphatase-induced CO release was monitored by means of GC. The biological activity was assessed in different cellular assays. The compounds were shown to be only slightly toxic, and a moderate anti-inflammatory potential was determined in an assay based on the inhibition of inducible NO synthase (iNOS)-induced NO production.
Regiochemistry of the Rearrangement of Cyclohexenyl and Cyclohexadienyl Phosphates to β-Keto Phosphonates
Gloer, Katherine B.,Calogeropoulou, Theodora,Jackson, John A.,Wiemer, David F.
, p. 2842 - 2846 (2007/10/02)
Diethyl vinyl phosphates derived from substituted cyclohexanones are known to rearrange to β-keto phosphonates upon treatment with excess LDA.To develop strategies for the regiocontrol of this rearrangement, the effect of regiospecific preparation of the
