940903-37-7 Usage
Description
Pyrimidine, 2-[4-(1-piperazinyl)phenyl]is a chemical compound characterized by a pyrimidine ring connected to a phenyl group that features a piperazine ring. This structure is frequently utilized in medicinal chemistry as a versatile scaffold for the creation of bioactive compounds, especially within the pharmaceutical research domain. The presence of the piperazine group allows for interactions with a range of biological targets, enhancing the compound's potential as a foundation for new drug development. Its unique structure and properties render it an invaluable asset in drug discovery and development, holding promise for the treatment of a variety of diseases and disorders.
Uses
Used in Pharmaceutical Research:
Pyrimidine, 2-[4-(1-piperazinyl)phenyl]serves as a crucial scaffold in the development of new pharmaceuticals. Its ability to engage with multiple biological targets makes it a key component in the design of innovative drugs.
Used in Drug Discovery:
Pyrimidine, 2-[4-(1-piperazinyl)phenyl]acts as a valuable tool in drug discovery, providing a foundation upon which researchers can build and modify to create effective treatments for a range of diseases and disorders.
Used in Medicinal Chemistry:
Pyrimidine, 2-[4-(1-piperazinyl)phenyl]is employed in medicinal chemistry as a versatile building block. Its structural attributes and capacity for interaction with biological targets make it instrumental in the synthesis of bioactive compounds.
Used in the Treatment of Various Diseases and Disorders:
Given its potential applications in drug development, Pyrimidine, 2-[4-(1-piperazinyl)phenyl]holds promise for the treatment of a variety of medical conditions, although specific applications would depend on the drugs developed using this compound as a base.
Check Digit Verification of cas no
The CAS Registry Mumber 940903-37-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,0,9,0 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 940903-37:
(8*9)+(7*4)+(6*0)+(5*9)+(4*0)+(3*3)+(2*3)+(1*7)=167
167 % 10 = 7
So 940903-37-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N4/c1-6-16-14(17-7-1)12-2-4-13(5-3-12)18-10-8-15-9-11-18/h1-7,15H,8-11H2
940903-37-7Relevant articles and documents
Charge-transfer-directed radical substitution enables para-selective C-H functionalization
Boursalian, Gregory B.,Ham, Won Seok,Mazzotti, Anthony R.,Ritter, Tobias
, p. 810 - 815 (2016)
Efficient C-H functionalization requires selectivity for specific C-H bonds. Progress has been made for directed aromatic substitution reactions to achieve ortho and meta selectivity, but a general strategy for para-selective C-H functionalization has remained elusive. Herein we introduce a previously unappreciated concept that enables nearly complete para selectivity. We propose that radicals with high electron affinity elicit arene-to-radical charge transfer in the transition state of radical addition, which is the factor primarily responsible for high positional selectivity. We demonstrate with a simple theoretical tool that the selectivity is predictable and show the utility of the concept through a direct synthesis of aryl piperazines. Our results contradict the notion, widely held by organic chemists, that radical aromatic substitution reactions are inherently unselective. The concept of radical substitution directed by charge transfer could serve as the basis for the development of new, highly selective C-H functionalization reactions.
