940933-23-3

Basic information

• Product Name: ethyl 2-(3-chloropyridin-2-yl)acetate
• Synonyms: ethyl 2-(3-chloropyridin-2-yl)acetate
• CAS NO: 940933-23-3
• Molecular Weight: 199.637
• Mol File: 940933-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-(3-chloropyridin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-chloropyridin-2-yl)acetate(940933-23-3)
• EPA Substance Registry System: ethyl 2-(3-chloropyridin-2-yl)acetate(940933-23-3)

Safety Data

• Hazardous Substances Data: 940933-23-3(Hazardous Substances Data)

Upstream product

• 1209007-36-2 ethyl 2-[(4-methoxybenzyl)amino]thieno[3,2-b]pyridine-3-carboxylate 

Downstream Products

• 1209008-31-0 1,1,1-trifluoro-2-methylpropan-2-yl 4-[4-({2-[(4-methoxybenzyl)amino]thieno[3,2-b]pyridin-3-yl}carbonyl)piperazin-1-yl]piperidine-1-carboxylate 
• 1209007-37-3 2-[(4-methoxybenzyl)amino]thieno[3,2-b]pyridine-3-carboxylic acid 
• 1209007-36-2 ethyl 2-[(4-methoxybenzyl)amino]thieno[3,2-b]pyridine-3-carboxylate 
• 885167-73-7 2-(3-chloropyridin-2-yl)acetic acid 
• 940933-05-1 3-chloro-5-(4-chlorophenyl)-4-(3-chloro-2-pyridyl)-6-methylpyridazine 
• 940933-08-4 5-(4-chlorophenyl)-4-(3-chloro-2-pyridyl)-3-methoxy-6-methyl pyridazine 
• 940933-24-4 5-(4-chlorophenyl)-4-(3-chloro-2-pyridyl)-6-methyl-2H-pyridazin-3-one 

Relevant articles and documents

Discovery of novel (4-piperidinyl)-piperazines as potent and orally active acetyl-CoA carboxylase 1/2 non-selective inhibitors: F-Boc and triF-Boc groups are acid-stable bioisosteres for the Boc group

Novel (4-piperidinyl)-piperazine derivatives were synthesized and evaluated as ACC1/2 non-selective inhibitors. Optimization of the substituents on the nitrogen of the piperidine ring led to the identification of the fluorine substituted tert-butoxycarbonyl group. Advanced analog, 1,1,1-trifluoro-2- methylpropan-2-yl 4-{4-[(2-amino-6-methyl-1-benzothiophen-3-yl)carbonyl] piperazin-1-yl}piperidine-1-carboxylate (12c) showed potent inhibitory activities in enzyme-assay and cell-based assays. Compound 12c also exhibited reduction of hepatic de novo fatty acid synthesis in rats after oral administration.