940941-30-0Relevant academic research and scientific papers
Solid-phase carbohydrate synthesis via on-bead protecting group chemistry
Branderhorst, Hilbert M.,Liskamp, Rob M.J.,Pieters, Roland J.
, p. 4290 - 4296 (2007/10/03)
Di- and tri-saccharides were synthesized on a solid phase. The procedure started with a non-protected sugar linked via either cysteine or glutamine to a polystyrene resin. Selective dimethoxytritylation chemistry and subsequent steps yielded a resin-bound acceptor that could be glycosylated to yield β1,6-linked disaccharides. Reiteration of the procedure produced the trisaccharide.
