940941-43-5Relevant academic research and scientific papers
Development of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent
Iikuni, Shimpei,Nakashima, Kazuma,Ono, Masahiro,Watanabe, Hiroyuki
supporting information, p. 6432 - 6435 (2021/07/02)
Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ligands, radiometals, and an albumin binder to be readily prepared. ADA exhibited promising properties as a theranostic platform.
THIOAMIDE-CONTAINING COMPOSITIONS AND METHODS OF USE THEREOF
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Page/Page column 22-23, (2020/06/05)
Provided herein are compositions and methods for preparing albumin-targeting moieties that feature a thioamide linkage. Methods to use the albumin targeting molecules to generate drugs with improved in vivo pharmacodynamics and biodistribution are described. Therapeutic compounds incorporating these thioamide linked albumin-targeting moieties are disclosed.
COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS
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Page/Page column 99; 100, (2015/03/28)
Compositions and methods for the treatment of fungal infections including compounds containing a pathogen pattern recognition receptor ligand and a β 1,3-glucan synthase inhibitor are disclosed. In particular, compounds containing a lipopeptide moiety and
COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS
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Page/Page column 53; 54, (2015/12/09)
Compositions and methods for the treatment of fungal infections including compounds containing a chemotaxis receptor ligand moiety and a polyene antifungal agent moiety are disclosed. In particular, compounds containing a polyene antifungal agent and a formyl peptide receptor ligand can be used in the treatment of fungal infections caused by a fungus of the genus Aspergillus or Candida.
