940965-03-7Relevant academic research and scientific papers
Total synthesis of marine sponge bis(indole) alkaloids of the topsentin class
Guinchard, Xavier,Vallee, Yannick,Denis, Jean-Noel
, p. 3972 - 3975 (2007)
(Chemical Equation Presented) The synthesis of four natural bis(indole) alkaloids of topsentin class 1 and 2 is described. Their bis(indole) α-carbonylimidazoline and subsequently bis(indole) α- carbonylimidazole moieties have been built via the condensation between indolic α-ketothioimidate salts 4 and l-(indol-3′-y1)-1,2-diaminoethane 3. This compound results from the β-amino indolic hydroxylamine 5 by a two-step sequence. This is the first total synthesis of compounds 1d, 2a, and 2b.
Three-Component Coupling-Oxidative Amidation-Heterocycloannulation: Synthesis of the Indole Alkaloids Hamacanthin A and trans -2,5-Bis(3′-Indolyl)piperazine
Srinivasan, A. Kaliyaperumal,Banerjee, Shyamapada,Pachore, Sharad S.,Syam Kumar
supporting information, p. 1057 - 1064 (2017/05/19)
Concise and highly convergent syntheses of antifungal marine bis(indole) alkaloids, hamacanthin A and trans-2,5-bis(3′-indolyl)piperazine is described. The total synthesis of hamacanthin A is accomplished via the oxidative amidation-chemoselective heterocycloannulation of 2,2-dibromo-1-(1H-indol-3-yl)ethanone with 1-(1H-indol-3-yl)ethane-1,2-diamine. The reduction of desbromo hamacanthin with aluminum borohydride afforded the alkaloid trans-2,5-bis(3′-indolyl)piperazine. Two novel and convenient protocols for the synthesis of indolyl-1,2-diaminoethane are also developed in moderate to good yields.
NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS
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Page/Page column 35-36, (2010/06/19)
The invention relates to the use of at least one compound of the formula (I), in which R and R3 are particularly a hydrogen atom, R1 is particularly a hydrogen atom or a methyl, ethyl or isobutyl mi group, R4, R5, R6 and R7 are independently a hydrogen atony, an alkoxyl group with 1 to 7 carbon atoms or a halogen atom, R2 is a hydrogen atom, an O? group or an OH group, B is an N-GP1 or NRc, group, GP1 being a Boc or Cbz group, and Rc is a hydrogen atom or a methyl or t-butyl group, for preparing a drug for treating conditions associated with bacterial infections, in particular for treating bacterial diseases.
