94098-94-9Relevant academic research and scientific papers
OH. Loss and Molecular Rearrangements of Quinoxaline N-Oxides Studied by Interpretation of Mass Spectra and Application of Linear Discriminant Analysis
Bartoszek, M.,Salzwedel, D.,Stumm, G.,Niclas, H.-J.
, p. 259 - 268 (1987)
Quinoxaline N-oxides substituted at the ortho position to the NO group give characteristic + fragments.With the di-N-oxides the peak intensities depend on the electron-withdrawing strength of the 2- and 3-substituents.Linear discriminant analysis was used to study the fragmentation of quinoxaline N-oxides as determined by the number of NO groups.Results of peak selection and discriminant analysis (Fisher quotients and discriminant vector coefficients) were interpreted with regard to the mass spectrometric decomposition of quinoxaline and quinoxaline N-oxide molecules.For the substituted quinoxaline N-oxides, fragmentations involving molecular rearrangements like those observed for unsubstituted quinoxaline N-oxides were also found.For these compounds, partial rearrangement to quinoxalines is confirmed.
Tandem C-N Bond Formation through Condensation and Metal-Free N-Arylation: Protocol for Synthesizing Diverse Functionalized Quinoxalines
Jiao, Yan-Xiao,Wu, Ling-Ling,Zhu, Hai-Miao,Qin, Jiang-Ke,Pan, Cheng-Xue,Mo, Dong-Liang,Su, Gui-Fa
, p. 4407 - 4414 (2017/04/28)
Diverse functionalized quinoxalines were synthesized in good yields from arylamines and readily available β-keto oximes through condensation and metal-free N-arylation. The reaction was compatible with various functional groups, such as halides, cyano, and esters. A mechanism was proposed based on the experimental results. These quinoxalines were easily obtained on a gram scale and converted to various useful scaffolds. Compound LASSBio-1022 was prepared in 83% yield in two steps.
The enthalpies of dissociation of the N-O bonds in two quinoxaline derivatives
Gomes, Jose R. B.,Monteiro, Andre R.,Campos, Bruno B.,Gomes, Paula,Ribeiro Da Silva, Maria D. M. C.
experimental part, p. 17 - 23 (2009/07/26)
The present work reports the first experimental thermochemical study of mono-N-oxides derived from quinoxaline, namely, 3-methoxycarbonyl-2-methyl- quinoxaline N-oxide and 3-ethoxycarbonyl-2-methyI-quinoxaIine N-oxide. The values of the enthalpies of formation, in the condensed state, and of the enthalpies of sublimation, derived from static bomb calorimetry and Calvet microcalorimetry measurements, respectively, are combined to derive the standard molar enthalpies of formation in the gaseous phase for these two compounds. From the latter values, the first and second N-O bond dissociation enthalpies for the corresponding di-N-oxides have been obtained. The gas-phase experimental results are also compared with calculated data obtained with a density functional theory approach. Copyright
Synthesis of the possible metabolites of quinocetone in animals
Li, Jian-Yong,Zhang, Ji-Yu,Zhou, Xu-Zheng,Li, Jin-Shan,Lu, Run-Hua
, p. 49 - 56 (2008/02/12)
The possible metabolites of quinocetone in animals had been prepared with different selective reagent by three synthetic routes. It was their principal reaction that Na2S2O4 reduced quinoxaline-1,4-dioxide derivatives to quinoxaline derivatives, H 2O2 s oxidized 2-carboxyl-quinoxaline derivatives to 2-carboxyl-quinoxaline-1 -oxide ones and P(OCH3) 3 reduced 2-carboxyl- quinoxaline-1,4-dioxide derivatives to 3-carboxyl-quinoxaline-1-oxide ones. The title compounds ware confirmed with NMR,UV, FAB-MS, et al.
