94109-22-5Relevant academic research and scientific papers
SUBSTITUTION OF HYDROGEN ATOMS IN PYRIMIDINOANTHRONE BY N- AND O-NUCLEOPHILES
Kazankov, M.V.,Zotova, O.A.
, p. 992 - 997 (2007/10/02)
The reaction of pyrimidinoanthrone with N- and O-nucleophiles leads to substitution of the hydrogen atoms at positions 4 and 6.The direction of nucleophilic attack depends on the reagent (ammonia, aromatic and aliphatic amines, hydroxide, alkoxide and phenoxide ions), the catalyst, and the reaction medium.The formation of disubstitution products (4,6-dialkylamino derivatives) was discovered for the first time in such reactions for the case of alkylamination.The factors that promote the regiospecificity and selectivity of substitution at position 4 were determined.
