941293-01-2

Upstream product

• 15359-98-5 4-(tert-butoxy)toluene 
• 941293-02-3 (S)-β-4-tert-butoxyphenyl-γ-(S)-N-benzyl-α-methylbenzylamino-propylalcohol 
• 941293-00-1 3-(4-tert-butoxyphenyl)propionaldehyde 
• 132307-87-0 3-(4-tert-butoxyphenyl)-propan-1-ol 

Downstream Products

• 941293-03-4 (s)-β-4-tert-butoxylphenyl-γ-Fmoc-amino-propylalcohol 
• 115134-37-7 Fmoc-OH 

Relevant academic research and scientific papers

Practical synthesis of enantiomerically pure β2-amino acids via proline-catalyzed diastereoselective aminomethylation of aldehydes

Proline-catalyzed diastereoselective aminomethylation of aldehydes using a chiral iminium ion, generated from a readily prepared precursor, provides α-substituted-β-amino aldehydes with 85:15 to 90: 10 dr. The α-substituted-β-amino aldehydes can be reduce

CONCISE BETA2-AMINO ACID SYNTHESIS VIA ORGANOCATALYTIC AMINOMETHYLATION

The present invention provides a method for the synthesis of ?2-amino acids. The method also provides methods yielding a-substituted ?-amino aldehydes and ?-substituted γ-amino alcohols. The present method according to this invention allows for increased yield and easier purification using minimal chromatography or crystallization. The methods described herein are based on an aldehyde aminomethylation which involves a Mannich reaction between an aldehyde and a formaldehyde-derived N,O-acetal (iminium precursor) and a catalyst, such as, for example, L-proline or a pyrrolidine. The invention allows for large scale, commercial preparation of ?2-amino acids.