94136-43-3

Upstream product

• 4797-81-3 N-benzyloxyacetamide 
• 94136-42-2 4--N-(benzyloxy)amino>-1-butyl bromide 
• 94136-39-7 N-Benzyloxy-N-(4-bromo-butyl)-acetamide 
• 108-80-5 isocyanuric acid 
• 108-24-7 acetic anhydride 
• 153756-35-5 Tris<-N-(benzyloxy)amino>butyl> isocyanurate 
• 590-28-3 potassium cyanate 

Relevant academic research and scientific papers

Iron transport-mediated drug delivery: Synthesis and biological evaluation of cyanuric acid-based siderophore analogs and β-lactam conjugates

Trihydroxamate-containing isocyanurates 4a-c were synthesized and determined to be capable of substituting for natural siderophores (microbial iron sequestering agents) in limited microbiological assays. The direct coupling of protected 4a to carbacephalosporins 16 and 17 and subsequent deprotection gave conjugates 20 and 21. The Lorabid conjugate 21 was especially active against E. ccoli X580 in preliminary biological tests, thus demonstrating the continued potential of siderophore-mediated drug delivery.

Artificial siderophores. 2. Syntheses of trihydroxamate analogues of rhodotorulic acid and their biological iron transport capabilities in Escherichia coli

Tris[(acetylhydroxyamino)alkyl] isocyanurates 2a-c were synthesized from α,ω-dibromoalkanes in four steps. The alkylation of the bromides with O-benzyl-N-[(trichloroethoxy)carbonyl]hydroxylamine in the presence of DBU gave N-alkylation products 7a-c. The