94142-16-2

Upstream product

• 94142-22-0 3-ethyl-6-(cyclohexyl)-3,4-dihydro-2-N-piperidino-2H-pyrane 
• 2177-34-6 1-cyclohexylprop-2-en-1-one 
• 38289-30-4 trans-4-n-trans-cyclohexanecarboxylic acid 
• 99419-30-4 ethylmalonaldehyde 
• 823-76-7 Cyclohexyl methyl ketone 
• 102-07-8 bis(diphenyl)urea 
• 94142-24-2 trans-1-n-hexyl-4-acetylcyclohexane 

Relevant academic research and scientific papers

PREPARATION OF PYRIDINE DERIVATIVES USING PYRIMIDINIUM DERIVATIVES AS INTERMEDIATES

A method in which a pyridinium derivative of formula (I) such as 1,3-dimethyl-2,3-dihydro-2-oxopyrimidinium chloride is reacted with an acetyl compound of formula (II) such as 4-acetylpyridine, and then the reaction product is reacted with ammonia or an ammonium salt to form a pyridine derivative of formula (III):Also disclosed is a method for the preparation of the compound of formula (I) from reacting a compound of formula (IV) or (V) with a compound of formula (VI):Also disclosed are two additional alternative methods for the preparation of compounds of formula (I) and related compounds. The substituents are defined in the claims.

SYNTHESIS OF 5-n-ALKYL-2-(trans-4-n-ALKYLCYCLOHEXYL)PYRIDINES

The cyclization of trans-1-acrylyl-4-n-alkylcyclohexanes with trans-1-N-piperidino-1-alkenes was used to synthesize 3-n-alkyl-6-(trans-4-n-alkyl-cyclohexyl)-3,4-dihydro-2-N-piperidino-2H-pyrans, which were converted under the influence of hydroxylamine to 5-n-alkyl-2-(trans-4-n-alkylcyclohexyl)-pyridines.Problems in the stereochemistry of the cyclohexane derivatives in the investigated scheme of synthesis were examined.