94145-22-9

Basic information

• Product Name: 1-benzyl-4-methyl-5-cyano-6-hydroxy-7-azaindoline
• CAS NO: 94145-22-9
• Molecular Weight: 265.315
• Mol File: 94145-22-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-benzyl-4-methyl-5-cyano-6-hydroxy-7-azaindoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-methyl-5-cyano-6-hydroxy-7-azaindoline(94145-22-9)
• EPA Substance Registry System: 1-benzyl-4-methyl-5-cyano-6-hydroxy-7-azaindoline(94145-22-9)

Safety Data

• Hazardous Substances Data: 94145-22-9(Hazardous Substances Data)

Upstream product

• 94145-21-8 2-benzylamino-3-(β-hydroxyethyl)-4-methyl-5-cyano-6-hydroxypyridine 
• 94145-19-4 benzylammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine 
• 94145-20-7 ammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine 
• 32383-14-5 4-methyl-5-cyano-6-hydroxy-2,3-dihydro-7-azabenzofuran 
• 100-46-9 benzylamine 

Downstream Products

• 105678-52-2 1-Benzyl-4-methyl-6-piperidin-1-yl-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile 
• 111837-88-8 1-benzyl-4,7-dimethyl-5-cyano-6-oxo-7-azaindoline 
• 111837-86-6 1-benzyl-4-methyl-5-cyano-6-methoxy-7-azaindoline 
• 105678-61-3 1-benzyl-4-methyl-5-cyano-6-piperidino-7-azaindoline 
• 96626-25-4 1-benzyl-4-methyl-5-cyano-6-chloro-7-azaindoline 

Relevant articles and documents

AZAINDOLE DERIVATIVES. 66. 1,6-DISUBSTITUTED 4-METHYL-5-CYANO-7-AZAINDOLINES

A general method was developed for the synthesis of 1,6-disubstituted 4-methyl-5-cyano-7-azaindolines from the readily available ammonium salt of 2,6-dihydroxy-3-(β-hydroxyethyl)-4-methyl-5-cyanopyridine through the corresponding N-substituted ammonium salts and N-substituted 2-amino-3-(β-hydroxyethyl)-4-methyl-5-cyano-6-hydroxypyridines with treatment of the latter by POCl3.This method gives a 40percent yield of 4-methyl-5-cyano-7-azaindoline compounds containing various aralkyl or alkyl substituents at N-1 and a hydroxy group or halogen atom at C-6 in three steps.