941579-10-8

Basic information

• Product Name: C₂₅H₂₆O₅
• Synonyms: C₂₅H₂₆O₅
• CAS NO: 941579-10-8
• Molecular Weight: 406.478
• Mol File: 941579-10-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₆O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₆O₅(941579-10-8)
• EPA Substance Registry System: C₂₅H₂₆O₅(941579-10-8)

Safety Data

• Hazardous Substances Data: 941579-10-8(Hazardous Substances Data)

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 286458-65-9 (R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-methyl-propionic acid methyl ester 

Downstream Products

• 941579-11-9 C₂₇H₂₇NO₅ 

Relevant articles and documents

Unexpected preference of the E. coli translation system for the ester bond during incorporation of backbone-elongated substrates

There have been recent advances in the ribosomal synthesis of various molecules composed of nonnatural ribosomal substrates. However, the ribosome has strict limitations on substrates with elongated backbones. Here, we show an unexpected loophole in the E. coli translation system, based on a remarkable disparity in its selectivity for β-amino/hydroxy acids. We challenged β-hydroxypropionic acid (β-HPA), which is less nucleophilic than β-amino acids but free from protonation, to produce a new repertoire of ribosome-compatible but main-chain-elongated substrates. PAGE analysis and mass-coupled S-tag assays of amber suppression experiments using yeast suppressor tRNAPheCUA confirmed the actual incorporation of β-HPA into proteins/oligopeptides. We investigated the side-chain effects of β-HPA and found that the side chain at position α and R stereochemistry of the β-substrate is preferred and even notably enhances the efficiency of incorporation as compared to the parent substrate. These results indicate that the E. coli translation machinery can utilize main-chain-elongated substrates if the pKa of the substrate is appropriately chosen.