94161-80-5

Usage

Uses

Used in Pharmaceutical Industry:
1(2H)-Pyridinecarboxylic acid, 2-(2-propenyl)-, methyl ester (9CI) is used as an intermediate in the synthesis of various drugs, particularly those with anti-inflammatory and analgesic properties. Its role in drug production is crucial for developing medications that can alleviate pain and reduce inflammation in patients.
Used in Perfume Industry:
In the perfume industry, 1(2H)-Pyridinecarboxylic acid, 2-(2-propenyl)-, methyl ester (9CI) is used as a component in the creation of various fragrances. Its strong, sweet odor makes it a desirable addition to the formulation of perfumes, contributing to the overall scent profile.
Used in Flavoring Industry:
Similarly, in the flavoring industry, 1(2H)-Pyridinecarboxylic acid, 2-(2-propenyl)-, methyl ester (9CI) is employed in the development of different taste profiles for food and beverages. Its unique odor and taste characteristics make it a valuable asset in the synthesis of flavoring agents.
Safety Precautions:
It is essential to handle 1(2H)-Pyridinecarboxylic acid, 2-(2-propenyl)-, methyl ester (9CI) with care and follow proper safety measures due to its potential health hazards. Appropriate personal protective equipment (PPE) and adherence to safety guidelines are necessary to minimize risks associated with its use.

Upstream product

• 86950-96-1 1-(methoxycarbonyl)pyridine-1-ium chloride 
• 1730-25-2 allylmagnesium bromide 
• 110-86-1 pyridine 
• 24850-33-7 allyltributylstanane 
• 79-22-1 methyl chloroformate 

Relevant academic research and scientific papers

Reaction of Allylic Tin Reagents with Nitrogen Heteroaromatics Activated by Alkyl Chloroformates: Regioselective Synthesis of α-Allylated 1,2-Dihydropyridines and Change of the Regioselectivity Depending on Methyl Substituents at the Allylic Moiety

Allyltin reagents readily react with pyridine and some substituted pyridines activated by alkyl chloroformates to give α-allylated 1,2-dihydropyridines regioselectively.Functional substituents such as halogeno, acetoxy, and formyl groups can be tolerated, demonstrating high chemoselectivity of the reactions.The regiochemistry of the attack on pyridine nuclei changes from α-addition to α- and γ-addition (nonregioselective) to γ-addition, depending on methyl substituents at the allylic moiety (from allyl to methallyl and crotyl to prenyl groups).It is also found that the reactions occur at the γ-position of allylic tin reagents, indicating SN2' character of the reactions.The present effective allylation method can be extended to isoquinoline and quinoline systems.

Highly Regioselective α-Allylation of N-(Alkoxycarbonyl)pyridinium Salts by means of Allyltin Reagents

N-(Alkoxycarbonyl)pyridinium salts are regioselectively allylated in the α-positions by means of allyltributyltin to give α-allyl-1,2-dihydropyridines in moderate to good yields.