94162-44-4

Upstream product

• 107-86-8 3,3-dimethyl acrylaldehyde 
• 71316-95-5 benzyloxymethyl lithium 
• 3017-69-4 2-methyl-1-propenylbromide 
• 60656-87-3 benzyloxyacetoaldehyde 

Downstream Products

• 94162-46-6 (E)-6-Benzyloxy-3,3-dimethyl-hex-4-enoic acid ethyl ester 
• 160509-06-8 4-Methyl-1-(phenylmethoxy)-3-penten-2-yl 3-oxobutanoate 
• 83004-73-3 N-((E)-5-Benzyloxy-2,2-dimethyl-pent-3-enyl)-3-[1,3]dioxan-2-yl-propionamide 
• 94202-33-2 (R)-2-Acetoxy-N-((E)-5-benzyloxy-2,2-dimethyl-pent-3-enyl)-succinamic acid 
• 94162-50-2 (R)-3-Acetoxy-N-((E)-5-benzyloxy-2,2-dimethyl-pent-3-enyl)-succinamic acid 
• 86534-22-7 (+)-4(R)-acetoxy-1-<5-(benzyloxy)-2,2-dimethylpent-3-(E)-en-1-yl>-2,5-pyrrolidinedione 
• 86545-49-5 4(R)-acetoxy-1-<5-(benzyloxy)-2,2-dimethylpent-3(E)-en-1yl>-5-hydroxy-2-pyrrolidinone 
• 94162-49-9 tert-butyl N-<5-(benzyloxy)-2,2-dimethylpent-3(E)-en-1-yl>urethane 
• 86534-21-6 5-(benzyloxy)-2,2-dimethylpent-3(E)-enamine 
• 94162-47-7 (E)-6-Benzyloxy-3,3-dimethyl-hex-4-enoyl azide 
• 94162-48-8 ((E)-5-Isocyanato-4,4-dimethyl-pent-2-enyloxymethyl)-benzene 
• 86534-20-5 6-(benzyloxy)-3,3-dimethyl-4-hexenoyl chloride 
• 94162-45-5 (E)-6-(benzyloxy)-3,3-dimethyl-4-hexenoic acid 

Relevant academic research and scientific papers

Intramolecular C-H insertion by an alkylidene carbene: Diastereoselective synthesis of a taxol A ring synthon

The first stage in a proposed total synthesis of the clinically effective anticancer agent taxol 1 is reported. A key step in this synthesis is the development of a new procedure for the generation and cyclization of the alkylidene carbene derived from ketone 9, to give cyclopentene 16 (formation of three new carbon-carbon bonds) in 72% yield. Ozonolysis of 16 followed by aldol condensation furnished the crystalline cyclohexenone 4.

N-Acyliminium Ion Rearrangements: Generalities and Application to the Synthesis of Pyrrolizidine Alkaloids

N-Acyliminium ions of the 2-aza-1,5-hexadienyl type frequently rearrange to isomeric ions by a process which is formally a 2-aza-Cope rearrangement.When gem-dimethyl substitution is present at C-4 of the initially formed N-acyliminium ion, the rearranged

REARRANGEMENTS OF N-ACYL-2-AZA-1,5-HEXADIENES: APPLICATION TO SYNTHESES OF TRAECHELANTHAMIDINE AND SUPINIDINE

Efficient syntheses of the pyrrolizidine bases traechelanthamidine (4) and supinidine (5) via an N-acyliminium ion rearrangement-cyclization are described.