94189-81-8Relevant academic research and scientific papers
Design and synthesis of α-carboxy phosphononucleosides
Debarge, Sebastien,Balzarini, Jan,Maguire, Anita R.
, p. 105 - 126 (2011/04/17)
Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.
A versatile one-pot procedure to phosphate monoesters and pyrophosphates using Di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite
Van Der Heden Van Noort, Gerbrand J.,Verhagen, Carlo P.,Van Der Horst, Maarten G.,Overkleeft, Herman S.,Van Der Marel, Gijsbert A.,Filippov, Dmitri V.
supporting information; experimental part, p. 4461 - 4464 (2009/05/11)
(Chemical Equation Presented) A one-pot procedure for the preparation of phosphoramidates, phosphorothioates, pyrophosphates, phosphodiesters, and phosphofluoridates has been devised using di(p-methoxybenzyl)-N,N- diisopropylphosphoramidite as the common phosphitylating reagent.
One step selective 5′-O-allylation of thymidine using microwave or ultrasound activation
Roy, Vincent,Colombeau, Ludovic,Zerrouki, Rachida,Krausz, Pierre
, p. 1829 - 1831 (2007/10/03)
An improved procedures for the synthesis of 5′-O-allylthymidine via one step selective allylation of thymidine using either ultrasound or microwave activation is described.
