94193-36-9

Basic information

• Product Name: 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID
• Synonyms: 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID;Butanoic acid, 4-(3-formyl-4-nitrophenoxy)-;4-(3-Formyl-4-nitrophenoxy)butanoic acid
• CAS NO: 94193-36-9
• Molecular Formula: C₁₁H₁₁NO₆
• Molecular Weight: 253.21
• Mol File: 94193-36-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 109-110 °C
• Boiling Point: 514.9°C at 760 mmHg
• Flash Point: 265.2°C
• Appearance: /
• Density: 1.398g/cm³
• Vapor Pressure: 1.98E-11mmHg at 25°C
• Refractive Index: 1.596
• PKA: 4.53±0.10(Predicted)
• CAS DataBase Reference: 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID(94193-36-9)
• EPA Substance Registry System: 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID(94193-36-9)

Safety Data

• Hazardous Substances Data: 94193-36-9(Hazardous Substances Data)

Usage

General Description

4-(3-Formyl-4-nitro-phenoxy)-butyric acid is a chemical compound that is characterized by the presence of a formyl group, a nitro group, and a phenoxy group. It is a butyric acid derivative, with a molecular structure consisting of a four-carbon chain attached to a phenyl ring. 4-(3-FORMYL-4-NITRO-PHENOXY)-BUTYRIC ACID is commonly used in various chemical and pharmaceutical applications, including as an intermediate in the synthesis of other organic compounds. Its chemical properties and structure make it suitable for use in research and industrial processes where specific functional groups are required for specific reactions or properties.

InChI:InChI=1/C11H11NO6/c13-7-8-6-9(3-4-10(8)12(16)17)18-5-1-2-11(14)15/h3-4,6-7H,1-2,5H2,(H,14,15)

Upstream product

• 2969-81-5 Ethyl 4-bromobutyrate 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 100-83-4 meta-hydroxybenzaldehyde 
• 99306-51-1 bis(3-formylphenyl) oxalate 
• 94193-35-8 ethyl 4-((3-formyl-4-nitrophenyl)oxy)butyrate 

Downstream Products

• 112859-42-4 ethyl 4-[3-[(1-methyl-2,4-dioxoimidazolidin-5-ylidene)methyl]-4-nitrophenoxy]butanoate 
• 1392043-89-8 4-(3-acrloyloxymethyl)-4-nitrophenoxybutanoic acid 
• 105728-48-1 N-cyclohexyl-N-methyl-4-<(3-hydroxymethyl)-4-nitrophenoxy>butyramide 
• 94193-38-1 N-Cyclohexyl-N-methyl-4-(3-formyl-4-nitrophenyl)-oxybutyramide 
• 105763-78-8 N-cyclohexyl-N-methyl-4-(4-amino-3-carboxyphenoxy)butyramide hydrochloride 
• 94192-71-9 7-{4-[2-(2,2-Dicyclohexyl-ethyl)-piperidin-1-yl]-4-oxo-butoxy}-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one 
• 94219-49-5 Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester 
• 94193-06-3 2,2-Dimethyl-propionic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester 

Relevant articles and documents

Hapten synthesis, monoclonal antibody production and immunoassay development for direct detection of 4-hydroxybenzehydrazide in chicken, the metabolite of nifuroxazide

Derivatization is usually employed in immunoassay for detection of metabolites of nitrofurans and avoiding derivatization could be preferable to achieve an efficient screening. In the study, we designed four haptens of 4-hydroxybenhydrazide (HBH), the nifuroxazide metabolite. The effect of hapten structures on antibody affinity were evaluated and one monoclonal antibody was produced by using the Hapten C with a linear alkalane spacer arm. After optimization, an enzyme linked-immunosorbent assay (ELISA) was established with an 50% inhibition concentration of 0.25 ng mL?1 for HBH, which could ensure the direct detection of HBH without derivatization. The limit of detection of the ELISA for HBH was 0.12 μg kg?1 with the recoveries of 90.1–96.2% and coefficient of variation (CV) values lower than 9.1%. In conclusion, we produced several high affinity antibodies to HBH with new designed hapten and developed an icELISA for the direct detection of HBH without derivatization in chicken.

Nifuraldezone hapten and artificial antigen as well as preparation method and application thereof

The invention relates to nifuraldezone hapten and artificial antigen as well as a preparation method and application thereof. The nifuraldezone hapten has a structural formula (I) or (II) shown in thedescription. The nifuraldezone artificial antigen is prepared by coupling the hapten of the formula (I) or (II) with a carrier protein. When the nifuraldezone artificial antigen is adopted to immunize animals, specific antibodies with high valences and high sensitivity can be obtained. By adopting the nifuraldezone hapten and antibodies prepared from same, novel means for establishing rapid, simple, cheap, sensitive and specific nifuraldezone detection methods can be provided.

Preparation methods and application of semicarbazide SEM derived hapten and artificial antigen

The invention discloses preparation methods and application of semicarbazide SEM derived hapten and artificial antigen. An active arm introduced by the hapten integrally keeps a characteristic structure of an SEM derivative and has no influences on electr