942-46-1

Basic information

• Product Name: l-Methylephedrine HCl
• Synonyms: l-Methylephedrine HCl;(1-hydroxy-1-phenyl-propan-2-yl)-dimethyl-azanium chloride;(1-hydroxy-1-phenylpropan-2-yl)-dimethylazanium chloride;(2-hydroxy-1-methyl-2-phenyl-ethyl)-dimethyl-ammonium chloride
• CAS NO: 942-46-1
• Molecular Formula: C₁₁H₁₇NO*ClH
• Molecular Weight: 215.71972
• Mol File: 942-46-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: l-Methylephedrine HCl(CAS DataBase Reference)
• NIST Chemistry Reference: l-Methylephedrine HCl(942-46-1)
• EPA Substance Registry System: l-Methylephedrine HCl(942-46-1)

Safety Data

• RIDADR: 1544
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 942-46-1(Hazardous Substances Data)

Usage

General Description

l-Methylephedrine HCl is a chemical compound that is classified as a sympathomimetic amine, acting as a stimulant on the central nervous system. It is commonly used in over-the-counter medications as a nasal decongestant, bronchodilator, and appetite suppressant. l-Methylephedrine HCl is a salt form of l-Methylephedrine, a naturally occurring alkaloid found in plants. It works by constricting blood vessels and reducing inflammation in the nasal passages, making it effective in relieving congestion and facilitating easier breathing. However, its use should be closely monitored, as it can have potential side effects such as increased blood pressure, heart palpitations, and insomnia. Additionally, misuse or abuse of l-Methylephedrine HCl can lead to addiction and adverse health consequences.

Upstream product

• 1201-56-5 (+/-)-N-methylephedrine 
• 552-79-4 (-)-N-methylephedrine 

Relevant articles and documents

Density and stability differences between enantiopure and racemic salts: Construction and structural analysis of a systematic series of crystalline salt forms of methylephedrine

A data set of systematically related solid-state structures of pharmaceutical relevance has been created and used to investigate structural impact on physical properties in 20 pairs of enantiopure and racemic methylephedrinium salts. The structures are described and compared through graph-set analysis and the crystal packing similarity features of Mercury CSD 2.3. The commonest graph-set motif, C22 (9), was found to be present in 22 of the 37 independent structures and was flexible enough to include both carboxylate and sulfonate functionalities. An equivalent C 12 (7) motif was present in all six halide structures investigated. Analysis of molecular structure found three common methylephedrinium cation conformations, while analysis of cation packing found six isostructural groups, each containing at least two salt structures and based on one of three common cation packing motifs. Melting points and crystallographically obtained densities were examined in detail for the 13 enantiopure and racemic structural pairs found to be chemically identical to each other. While average densities conform to Wallach's rule, 6 of the 13 individual pairings do not. This does not support the structural justification normally given for Wallach's rule. One of the three observed common cation packing motifs is highly associated with failure of Wallach's rule, as are significant differences in hydrogen bonding between the enantiopure and racemic structures.