942076-74-6

Basic information

• Product Name: N-(4-Methoxybenzyl)-4-nitropyridin-2-aMine
• Synonyms: N-[(4-methoxyphenyl)methyl]-4-nitropyridin-2-amine
• CAS NO: 942076-74-6
• Molecular Formula: C₁₃H₁₃N₃O₃
• Molecular Weight: 259
• Mol File: 942076-74-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-(4-Methoxybenzyl)-4-nitropyridin-2-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxybenzyl)-4-nitropyridin-2-aMine(942076-74-6)
• EPA Substance Registry System: N-(4-Methoxybenzyl)-4-nitropyridin-2-aMine(942076-74-6)

Safety Data

• Hazardous Substances Data: 942076-74-6(Hazardous Substances Data)

Usage

General Description

N-(4-Methoxybenzyl)-4-nitropyridin-2-amine is a chemical compound with the molecular formula C13H12N2O3. It is a derivative of 4-nitropyridine and contains a benzyl and a methoxy group attached to the nitrogen atom. N-(4-Methoxybenzyl)-4-nitropyridin-2-aMine is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various organic molecules and pharmaceutical compounds. It has also been studied for its potential biological or pharmacological activities. This chemical may have applications in the development of new drugs or in the field of medicinal chemistry.

Upstream product

• 942076-73-5 N-(4-methoxybenzyl)-4-nitropyridin-2-amine 1-oxide 
• 14432-16-7 2-chloro-4-nitropyridine-N-oxide 
• 2393-23-9 4-methoxy-benzylamine 

Downstream Products

• 1274816-90-8 N-[(2R)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide 
• 1274817-11-6 N-[(2S)-7-((2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalen-2-yl]-3-[(dimethylamino)methyl]-5-(trifluoromethyl)benzamide hydrochloride 
• 942072-08-4 ((R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 
• 942073-62-3 ((S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]-7-(2-[(cyclopropylcarbonyl)amino]pyridin-4-yl)oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide 
• 4487-50-7 2-amino-4-nitropyridine 

Relevant articles and documents

Crystal Forms And Salt Forms Of 7h-Pyrrolo[2,3-D]Pyrimidine Compounds And Preparation Method Thereof

The present invention discloses crystal forms and salt forms of a 7H-pyrrolo[2,3-d]pyrimidine compounds and preparation methods thereof, and further discloses use of the crystal forms and the salt forms in the manufacture of a medicament for treating arthritis.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

This invention provides compounds of formula (I): wherein R1a, R1b, R1c, R2a, R2b, R2c, and R2d have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors

Inhibition of mutant B-Raf signaling, through either direct inhibition of the enzyme or inhibition of MEK, the direct substrate of Raf, has been demonstrated preclinically to inhibit tumor growth. Very recently, treatment of B-Raf mutant melanoma patients with a selective B-Raf inhibitor has resulted in promising preliminary evidence of antitumor activity. This article describes the design and optimization of tetrahydronaphthalene-derived compounds as potent inhibitors of the Raf pathway in vitro and in vivo. These compounds possess good pharmacokinetic properties in rodents and inhibit B-Raf mutant tumor growth in mouse xenograft models.